A case-control study on the association of mineral elements exposure and thyroid tumor and goiter.
Case-Control Studies
Child, Preschool
Female
Goiter
/ epidemiology
Humans
Iodine
/ urine
Linear Models
Male
Metals, Heavy
/ metabolism
Minerals
/ metabolism
Multivariate Analysis
Thyroid Function Tests
Thyroid Gland
/ metabolism
Thyroid Neoplasms
/ epidemiology
Trace Elements
/ metabolism
Young Adult
Association
Case-control study
Mineral elements
Thyroid function
Thyroid tumor and goiter
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Jan 2021
15 Jan 2021
Historique:
received:
06
08
2020
revised:
31
10
2020
accepted:
04
11
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
22
1
2021
Statut:
ppublish
Résumé
Thyroid tumor and thyroid goiter are prevalent disease around the world. In this case-control study, we investigated the association between exposure to a total of twelve mineral elements and thyroid disease as well as thyroid functions. Participants with thyroid tumor or goiter (N = 197) were matched with a healthy population (N = 197) by age (± 2 years old) and same sex. Questionnaires were used to collect data about the demographic characteristics and information of subjects. Serum and urine samples were collected simultaneously for each of the subjects. Mineral elements, iodine level of urine and levels of the total seven thyroid function indexes in serum were detected respectively. Conditional logistic regression was applied to estimate the associations between mineral elements and the risk of thyroid tumor and goiter through single-element models and multiple-element models. Multiple linear regression was used to evaluate relationships between mineral elements and percentage changes of thyroid functions. Higher concentrations of mineral elements in the recruited population were found in this study than other comparable studies, and the levels of chromium (Cr), manganese (Mn), nickel (Ni), arsenic (As), cadmium (Cd), selenium (Se), antimony (Sb), thallium (Tl) and lead (Pb) in the case group were lower than the control group. According to the single-element models, Cr, Mn, Ni, Sb and Tl showed significant negative associations with the risk of thyroid tumor and goiter, and, Cd showed nonmonotonic dose response. Cd and mercury (Hg) showed a nonmonotonic percentage change with T4, while Tl was associated with the increased FT4 in the control group. Therefore, Cd, Hg and Tl may disturb the balance of thyroid function to some extent, and Cr, Mn, Ni, Cd, Sb, and Tl may become potential influencing factors for the risk of thyroid tumor and goiter.
Identifiants
pubmed: 33396135
pii: S0147-6513(20)31452-4
doi: 10.1016/j.ecoenv.2020.111615
pii:
doi:
Substances chimiques
Metals, Heavy
0
Minerals
0
Trace Elements
0
Iodine
9679TC07X4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111615Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.