Dependence of Leydig Cell's Mitochondrial Physiology on Luteinizing Hormone Signaling.
LH
Leydig cell
cAMP
mitochondrial dynamics
mitoenergetics
mitosteroidogenesis
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
received:
24
11
2020
revised:
23
12
2020
accepted:
29
12
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
6
1
2021
Statut:
epublish
Résumé
Knowledge about the relationship between steroidogenesis and the regulation of the mitochondrial bioenergetics and dynamics, in steroidogenic cells, is not completely elucidated. Here we employed in vivo and ex vivo experimental models to analyze mitochondrial physiology in Leydig cells depending on the different LH-cAMP environments. Activation of LH-receptor in rat Leydig cells ex and in vivo triggered cAMP, increased oxygen consumption, mitoenergetic and steroidogenic activities. Increased mitoenergetic activity i.e., ATP production is achieved through augmented glycolytic ATP production and a small part of oxidative phosphorylation (OXPHOS). Transcription of major genes responsible for mitochondrial dynamics was upregulated for
Identifiants
pubmed: 33396202
pii: life11010019
doi: 10.3390/life11010019
pmc: PMC7824612
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Serbian Ministry of Education and Technological Development
ID : 173057
Organisme : Autonomic Province of Vojvodina
ID : 3822 and 2130
Organisme : Serbian Ministry of Education and Technological Development
ID : CeRes
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