Circulating Non-Coding RNAs in Head and Neck Cancer: Roles in Diagnosis, Prognosis, and Therapy Monitoring.


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
31 12 2020
Historique:
received: 21 11 2020
revised: 27 12 2020
accepted: 28 12 2020
entrez: 5 1 2021
pubmed: 6 1 2021
medline: 29 6 2021
Statut: epublish

Résumé

Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and recurrence. Recently, non-coding RNAs, including tRNA halves, YRNA fragments, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs), have been identified in the blood and saliva of patients diagnosed with HNC. These observations have recently fueled the study of their potential use in early detection, diagnosis, and risk assessment. The present review focuses on recent insights and the potential impact that circulating non-coding RNA evaluation may have on clinical decision-making in the management of HNC.

Identifiants

pubmed: 33396240
pii: cells10010048
doi: 10.3390/cells10010048
pmc: PMC7823329
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
RNA, Untranslated 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Araceli Diez-Fraile (A)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Joke De Ceulaer (J)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Charlotte Derpoorter (C)

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, 9000 Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (C.R.I.G.), 9000 Ghent, Belgium.

Christophe Spaas (C)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Tom De Backer (T)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Philippe Lamoral (P)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Johan Abeloos (J)

Division of Oral and Maxillofacial Surgery, Department of Surgery, AZ Sint-Jan Brugge-Oostende A.V., 8000 Bruges, Belgium.

Tim Lammens (T)

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, 9000 Ghent, Belgium.
Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Cancer Research Institute Ghent (C.R.I.G.), 9000 Ghent, Belgium.

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