Protective Role of Nrf2 in Renal Disease.
Nrf2
acute kidney injury
and inflammatory response
oxidative stress
renal disease
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
received:
07
11
2020
revised:
26
12
2020
accepted:
27
12
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
6
1
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.
Identifiants
pubmed: 33396350
pii: antiox10010039
doi: 10.3390/antiox10010039
pmc: PMC7824104
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI17/00130
Références
PLoS One. 2015 May 08;10(5):e0125726
pubmed: 25954969
PLoS One. 2012;7(12):e51111
pubmed: 23236440
Exp Cell Res. 2017 Nov 15;360(2):292-302
pubmed: 28928081
Int J Mol Sci. 2019 Aug 03;20(15):
pubmed: 31382550
Redox Biol. 2013 Oct 31;1:527-31
pubmed: 24363993
J Clin Invest. 2006 Apr;116(4):984-95
pubmed: 16585964
Arthritis Res Ther. 2016 Jun 14;18(1):139
pubmed: 27301376
Free Radic Biol Med. 2013 Aug;61:285-97
pubmed: 23567192
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6
pubmed: 22872865
Genes Dev. 2014 Apr 1;28(7):708-22
pubmed: 24636985
Int Urol Nephrol. 2015 Dec;47(12):1985-91
pubmed: 26490557
J Biol Chem. 2007 Dec 14;282(50):36412-20
pubmed: 17925401
Pediatr Nephrol. 2012 Jun;27(6):901-9
pubmed: 21947270
J Am Soc Nephrol. 2016 Jan;27(1):172-88
pubmed: 25999406
Nat Rev Drug Discov. 2019 Apr;18(4):295-317
pubmed: 30610225
Cancer Res. 2017 Sep 15;77(18):4797-4808
pubmed: 28655791
J Am Soc Nephrol. 2012 Jun;23(6):967-9
pubmed: 22499588
Yonsei Med J. 2016 May;57(3):664-73
pubmed: 26996567
J Cell Physiol. 2019 Aug;234(10):18994-19009
pubmed: 30919976
Int Immunopharmacol. 2016 Nov;40:517-523
pubmed: 27764742
J Am Soc Nephrol. 2002 Apr;13(4):1126-8
pubmed: 11912276
Free Radic Biol Med. 2014 Aug;73:260-9
pubmed: 24858719
Am J Nephrol. 2014;40(5):441-50
pubmed: 25427663
J Ren Nutr. 2016 Jul;26(4):237-44
pubmed: 26915483
Autophagy. 2016 Oct 2;12(10):1902-1916
pubmed: 27427974
Nat Rev Drug Discov. 2013 Dec;12(12):931-47
pubmed: 24287781
Acta Clin Croat. 2012 Dec;51(4):555-62
pubmed: 23540163
Biochem Biophys Res Commun. 2007 Dec 28;364(4):966-71
pubmed: 17971305
J Card Fail. 2014 Dec;20(12):953-8
pubmed: 25307295
Sci Rep. 2017 Oct 26;7(1):14130
pubmed: 29074861
Redox Biol. 2019 Sep;26:101275
pubmed: 31349118
Xenobiotica. 2014 Jun;44(6):570-8
pubmed: 24195589
Mol Nutr Food Res. 2013 Mar;57(3):504-15
pubmed: 23281030
Biochem Pharmacol. 2008 Jun 1;75(11):2214-23
pubmed: 18407246
Biomed Res Int. 2017;2017:1516985
pubmed: 28194406
PLoS One. 2012;7(10):e45870
pubmed: 23056222
Pharmacol Ther. 2010 Mar;125(3):436-45
pubmed: 20117134
J Nutr Biochem. 2015 Dec;26(12):1401-13
pubmed: 26419687
Mol Cell Biol. 2004 Dec;24(24):10941-53
pubmed: 15572695
Diabetes. 2014 Sep;63(9):3091-103
pubmed: 24740568
Toxicol Appl Pharmacol. 2008 Sep 15;231(3):364-73
pubmed: 18617210
Int Immunopharmacol. 2015 Oct;28(2):1003-8
pubmed: 26321118
Exp Ther Med. 2017 Nov;14(5):4460-4466
pubmed: 29067120
Microb Pathog. 2019 Dec;137:103688
pubmed: 31445125
Nephrol Dial Transplant. 2018 May 1;33(5):771-783
pubmed: 29126308
Kidney Int. 2017 Nov;92(5):1071-1083
pubmed: 28890325
Pharmacol Ther. 2013 Feb;137(2):153-71
pubmed: 23041058
J Pineal Res. 2012 May;52(4):460-9
pubmed: 22288898
FASEB J. 2007 Jul;21(9):2237-46
pubmed: 17384144
Am J Physiol Renal Physiol. 2001 Nov;281(5):F948-57
pubmed: 11592952
Breast Cancer Res Treat. 2011 Oct;129(3):983-91
pubmed: 21638050
J Am Soc Nephrol. 2014 Dec;25(12):2689-701
pubmed: 24925726
Sci Rep. 2016 Dec 12;6:38619
pubmed: 27941837
Int J Mol Sci. 2019 Jul 15;20(14):
pubmed: 31311094
Adv Exp Med Biol. 2019;1165:585-604
pubmed: 31399986
Nat Genet. 2019 Jun;51(6):957-972
pubmed: 31152163
Oxid Med Cell Longev. 2016;2016:4350965
pubmed: 26998193
Antioxid Redox Signal. 2010 Oct 1;13(7):1087-123
pubmed: 20170402
Diabetes. 2011 Nov;60(11):3055-66
pubmed: 22025779
Oxid Med Cell Longev. 2019 Dec 18;2019:4657651
pubmed: 31929854
Front Pharmacol. 2019 May 15;10:517
pubmed: 31156435
Lancet. 2002 Jul 20;360(9328):219-23
pubmed: 12133657
Lab Invest. 1984 Oct;51(4):396-403
pubmed: 6090809
Pharmacology. 2015;95(3-4):193-200
pubmed: 25924598
Basic Clin Pharmacol Toxicol. 2015 Sep;117(3):164-72
pubmed: 25625183
Adv Chronic Kidney Dis. 2018 Mar;25(2):166-180
pubmed: 29580581
Arch Biochem Biophys. 2017 Mar 1;617:84-93
pubmed: 27497696
Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71
pubmed: 20007347
Int Immunopharmacol. 2016 Mar;32:55-61
pubmed: 26800098
Biochem Pharmacol. 2016 Feb 1;101:71-86
pubmed: 26588861
PLoS One. 2013 Oct 28;8(10):e77847
pubmed: 24204994
Am J Nephrol. 2017;45(6):473-483
pubmed: 28502971
J Inj Violence Res. 2016 Jan;8(1):58-62
pubmed: 26804946
Sci Rep. 2016 Nov 02;6:36185
pubmed: 27804998
Antioxid Redox Signal. 2011 Oct 15;15(8):2135-46
pubmed: 21504366
FASEB J. 2019 Aug;33(8):8961-8975
pubmed: 31034781
J Biochem Mol Toxicol. 2018 Apr;32(4):e22044
pubmed: 29457851
Nat Commun. 2019 Aug 26;10(1):3842
pubmed: 31451708
Toxicol Lett. 2010 Feb 15;192(3):278-85
pubmed: 19913604
Diabetes. 2010 Apr;59(4):850-60
pubmed: 20103708
Curr Opin Nephrol Hypertens. 2014 Jan;23(1):9-16
pubmed: 24231312
Histochem Cell Biol. 2004 Aug;122(2):139-49
pubmed: 15258770
Antioxid Redox Signal. 2017 May 10;26(14):748-762
pubmed: 26914345
Arch Biochem Biophys. 2017 Mar 1;617:101-105
pubmed: 27665998
PLoS One. 2015 Jul 29;10(7):e0134139
pubmed: 26222683
Environ Toxicol. 2018 Jan;33(1):72-82
pubmed: 29064158
Biochim Biophys Acta. 2015 Jan;1852(1):34-46
pubmed: 25446993
BMC Dermatol. 2015 Jul 14;15:10
pubmed: 26170027
FASEB J. 2011 Mar;25(3):1076-87
pubmed: 21097520
Mol Cells. 2016 Jan;39(1):65-71
pubmed: 26813662
Kidney Int. 2017 Feb;91(2):387-401
pubmed: 27789056
Oncogene. 2013 Aug 8;32(32):3765-81
pubmed: 22964642
Biochim Biophys Acta. 2008 May;1783(5):713-27
pubmed: 18241676
Acta Cir Bras. 2019 Feb 14;34(1):e20190010000003
pubmed: 30785504
Biomed Res Int. 2014;2014:315494
pubmed: 25126552
J Biol Chem. 2002 Nov 22;277(47):44765-71
pubmed: 12235164
Oxid Med Cell Longev. 2017;2017:7612182
pubmed: 29435098
Am J Nephrol. 2014;39(6):499-508
pubmed: 24903467
Kidney Int. 2021 Jan;99(1):102-116
pubmed: 32818518
Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov;392(11):1331-1345
pubmed: 31197431
Scand J Urol Nephrol. 2011 Nov;45(5):365-70
pubmed: 21627399
Am J Physiol Renal Physiol. 2011 May;300(5):F1180-92
pubmed: 21289052
Molecules. 2014 Jul 10;19(7):10074-89
pubmed: 25014534
Nat Commun. 2019 Jan 3;10(1):29
pubmed: 30604766
Nature. 2011 Jul 06;475(7354):106-9
pubmed: 21734707
Antioxid Redox Signal. 2018 Dec 10;29(17):1756-1773
pubmed: 28793787
Mol Cancer Ther. 2007 Jan;6(1):154-62
pubmed: 17237276
Nephrol Dial Transplant. 2014 Apr;29(4):783-91
pubmed: 24523358
N Am J Med Sci. 2013 Mar;5(3):213-9
pubmed: 23626958
Nutr Metab (Lond). 2012 Apr 17;9(1):32
pubmed: 22510431
N Engl J Med. 2014 Jul 3;371(1):58-66
pubmed: 24988558
J Am Soc Nephrol. 2015 Dec;26(12):2989-3000
pubmed: 26293820
N Engl J Med. 2013 Dec 26;369(26):2492-503
pubmed: 24206459
Phytomedicine. 2013 Feb 15;20(3-4):359-66
pubmed: 23271001
Cell Death Dis. 2013 Oct 31;4:e899
pubmed: 24176857
Diabetes Metab. 2019 Jan;45(1):53-59
pubmed: 29983230
Genes Cells. 2008 Nov;13(11):1159-70
pubmed: 19090810
Kidney Int Rep. 2020 Apr 14;5(6):879-890
pubmed: 32518870
Endocrinology. 2018 Feb 1;159(2):836-852
pubmed: 29211853
Semin Hematol. 1989 Apr;26(2):105-13
pubmed: 2658086
Toxicol Lett. 2016 Sep 30;259:52-59
pubmed: 27480280
Kidney Int. 2001 Oct;60(4):1343-53
pubmed: 11576348
Oxid Med Cell Longev. 2018 Sep 3;2018:4035310
pubmed: 30250633
Neurology. 2017 May 16;88(20):1942-1950
pubmed: 28424271
Mol Cell Biol. 2014 Feb;34(4):653-63
pubmed: 24298019
Behav Brain Res. 2018 Jan 15;336:32-39
pubmed: 28851669
Antioxid Redox Signal. 2015 Sep 20;23(9):734-46
pubmed: 25891126
Mol Cell Biol. 2005 Dec;25(24):10895-906
pubmed: 16314513
Mol Cell Biol. 2006 Apr;26(8):2887-900
pubmed: 16581765
Mucosal Immunol. 2020 Jan;13(1):22-33
pubmed: 31719643
Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F808-19
pubmed: 23136004
Mol Cell Biol. 2002 May;22(9):2883-92
pubmed: 11940647
Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C390-C397
pubmed: 31091144
Nephrol Dial Transplant. 2013 Aug;28(8):2038-45
pubmed: 23512109
Arthritis Rheumatol. 2014 Nov;66(11):3129-39
pubmed: 25047252
Toxicol Sci. 2001 Sep;63(1):143-8
pubmed: 11509754
Antioxid Redox Signal. 2018 Dec 10;29(17):1727-1745
pubmed: 28899199
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):585-597
pubmed: 27825853
Toxicol Appl Pharmacol. 2016 Aug 1;304:1-8
pubmed: 27211841
Am J Physiol Renal Physiol. 2000 Sep;279(3):F525-31
pubmed: 10966932
J Biol Chem. 2005 May 27;280(21):20340-8
pubmed: 15790560
J Nutr Biochem. 2015 Jun;26(6):596-606
pubmed: 25724107
Biofactors. 2019 May;45(3):471-478
pubmed: 30893507
Lancet. 2017 Mar 25;389(10075):1238-1252
pubmed: 27887750
Annu Rev Pharmacol Toxicol. 2013;53:401-26
pubmed: 23294312
Free Radic Biol Med. 2011 Jun 1;50(11):1503-16
pubmed: 21376112
Chem Biol Interact. 2019 Aug 25;309:108689
pubmed: 31173751
J Am Soc Nephrol. 2015 Dec;26(12):2938-46
pubmed: 26152271
Clin Kidney J. 2019 Feb 14;12(2):258-261
pubmed: 30976406
Cytokine Growth Factor Rev. 2008 Apr;19(2):133-44
pubmed: 18358427
World J Urol. 2008 Jun;26(3):285-91
pubmed: 18373094
Eur J Pharmacol. 2011 Nov 30;670(2-3):578-85
pubmed: 21925163
Free Radic Biol Med. 2011 Aug 1;51(3):744-54
pubmed: 21641991
Redox Biol. 2017 Apr;11:543-553
pubmed: 28104575
PLoS One. 2013 Oct 28;8(10):e77794
pubmed: 24204969
Cell Physiol Biochem. 2017;43(5):2143-2154
pubmed: 29065403
Mol Cell Biol. 2012 Sep;32(17):3486-99
pubmed: 22751928
Compr Physiol. 2012 Apr;2(2):1303-53
pubmed: 23798302
Pharmacol Ther. 2015 Jul;151:72-86
pubmed: 25797698
J Pharmacol Exp Ther. 2011 Jun;337(3):583-90
pubmed: 21357516
Blood. 2010 Nov 18;116(20):4338-48
pubmed: 20709907
Oxid Med Cell Longev. 2012;2012:269039
pubmed: 22919438
Genes Cells. 2001 Oct;6(10):857-68
pubmed: 11683914
Front Pharmacol. 2018 Jun 18;9:638
pubmed: 29967581
Nat Rev Nephrol. 2011 Apr;7(4):209-17
pubmed: 21343898
J Biol Chem. 2006 Dec 29;281(52):39776-84
pubmed: 17077087
Am J Nephrol. 2011;33(5):469-76
pubmed: 21508635
J Biol Chem. 2003 Apr 4;278(14):12029-38
pubmed: 12556532
Free Radic Biol Med. 2013 Sep;64:4-11
pubmed: 23880293
Front Pharmacol. 2019 Jul 03;10:740
pubmed: 31333462
Biomed Pharmacother. 2018 Dec;108:1866-1878
pubmed: 30372892
BMC Nephrol. 2013 Mar 04;14:56
pubmed: 23496811
J Toxicol Pathol. 2019 Apr;32(2):79-89
pubmed: 31092974
Free Radic Biol Med. 2015 Nov;88(Pt B):199-204
pubmed: 26117325
Cell Physiol Biochem. 2018;45(4):1677-1689
pubmed: 29490296
Am J Physiol Renal Physiol. 2006 Dec;291(6):F1274-80
pubmed: 16868309
Redox Biol. 2020 Jan;28:101336
pubmed: 31590045
Nat Commun. 2016 May 23;7:11624
pubmed: 27211851
Eur J Pharmacol. 2019 Aug 15;857:172422
pubmed: 31152701
Kidney Int. 2007 Aug;72(3):247-59
pubmed: 17568785
Biomed Pharmacother. 2016 Aug;82:685-92
pubmed: 27470412
Fundam Clin Pharmacol. 2005 Aug;19(4):473-7
pubmed: 16011735
Crit Care. 2011;15(5):230
pubmed: 21996422
Biochim Biophys Acta. 2013 May;1830(5):3143-53
pubmed: 22995213
Kidney Int. 2012 Feb;81(4):338-40
pubmed: 22289794
PLoS One. 2015 Mar 18;10(3):e0119543
pubmed: 25785827
J Nutr Biochem. 2013 Jan;24(1):146-55
pubmed: 22819547
Curr Opin Nephrol Hypertens. 2006 Jan;15(1):72-7
pubmed: 16340670
Antioxid Redox Signal. 2014 Dec 20;21(18):2469-82
pubmed: 24844779
Antioxid Redox Signal. 2011 Oct 15;15(8):2335-81
pubmed: 21194351
Free Radic Biol Med. 2019 Apr;134:9-22
pubmed: 30599261
J Pathol. 2018 Mar;244(3):296-310
pubmed: 29205354
Nephrol Dial Transplant. 2013 Nov;28(11):2841-50
pubmed: 24169612
Nutrients. 2017 Jul 07;9(7):
pubmed: 28686196
Genes Dev. 1999 Jan 1;13(1):76-86
pubmed: 9887101
Arch Toxicol. 2003 Dec;77(12):685-93
pubmed: 13680094
Lancet. 2008 Nov 29;372(9653):1863-1865
pubmed: 19041789
Int J Exp Pathol. 2011 Jun;92(3):202-10
pubmed: 20804541
J Pharmacol Exp Ther. 2010 Oct;335(1):2-12
pubmed: 20605904
J Biol Chem. 2009 May 15;284(20):13291-5
pubmed: 19182219
Sci Rep. 2017 Aug 31;7(1):10114
pubmed: 28860665
Environ Toxicol. 2018 Mar;33(3):325-332
pubmed: 29214717
Trends Biochem Sci. 2014 Apr;39(4):199-218
pubmed: 24647116
Am J Kidney Dis. 2006 Nov;48(5):752-60
pubmed: 17059994
Cancer Med. 2019 May;8(5):2252-2267
pubmed: 30929309
Kidney Int. 2009 Aug;76(3):277-85
pubmed: 19436334
J Am Soc Nephrol. 2004 Jan;15(1):61-7
pubmed: 14694158
Neurobiol Dis. 2011 Oct;44(1):142-51
pubmed: 21757005
Open Access J Urol. 2010 Apr 22;2:41-55
pubmed: 24198613
Int Immunopharmacol. 2018 Aug;61:277-282
pubmed: 29906742
Free Radic Biol Med. 2015 Sep;86:374-81
pubmed: 25930007
Redox Biol. 2018 May;15:513-521
pubmed: 29413963
Sci Transl Med. 2017 Jun 14;9(394):
pubmed: 28615356
Free Radic Biol Med. 2015 Dec;89:431-42
pubmed: 26415026
Free Radic Biol Med. 2009 Nov 1;47(9):1304-9
pubmed: 19666107
Cell. 2016 Jun 2;165(6):1312-1313
pubmed: 27259142
Kidney Int. 2014 Feb;85(2):333-343
pubmed: 24025640
Cell. 2016 Jun 2;165(6):1361-1374
pubmed: 27259148
Eur J Pharmacol. 2015 Jul 15;759:205-20
pubmed: 25814248
J Biol Chem. 1983 Oct 10;258(19):12069-72
pubmed: 6619154
Toxicol Sci. 2011 Oct;123(2):590-600
pubmed: 21775727
Mol Nutr Food Res. 2013 Sep;57(9):1649-59
pubmed: 23174956
Free Radic Biol Med. 2009 Feb 15;46(4):443-53
pubmed: 19028565
J Am Soc Nephrol. 2014 Nov;25(11):2559-72
pubmed: 24925724
Cell Rep. 2016 Sep 6;16(10):2605-2617
pubmed: 27568559
Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1924-1931
pubmed: 28485784
Cancer Cell. 2012 Jul 10;22(1):66-79
pubmed: 22789539
Mol Biol Rep. 2012 Dec;39(12):11201-16
pubmed: 23070905
Mol Cell. 2009 Oct 9;36(1):131-40
pubmed: 19818716
Mol Cell Biol. 2009 May;29(10):2658-72
pubmed: 19273602
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):216-224
pubmed: 29304308
Shock. 2000 Feb;13(2):110-6
pubmed: 10670840
Toxicol Appl Pharmacol. 2009 Nov 15;241(1):81-9
pubmed: 19682480
Sci Rep. 2015 Jul 24;5:12377
pubmed: 26205695
Oxid Med Cell Longev. 2016;2016:2075915
pubmed: 26798413
Front Mol Neurosci. 2011 Nov 16;4:40
pubmed: 22110425
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7094-9
pubmed: 15103025
Nat Rev Nephrol. 2014 Sep;10(9):493-503
pubmed: 24981817
PLoS One. 2010 Jan 05;5(1):e8579
pubmed: 20062804
Cell Mol Life Sci. 2016 Sep;73(17):3221-47
pubmed: 27100828
Drug Des Devel Ther. 2014 Oct 23;8:2075-88
pubmed: 25364233
PLoS One. 2013 Sep 17;8(9):e74871
pubmed: 24069362
Biochim Biophys Acta. 2015 Oct;1849(10):1277-88
pubmed: 26291278
FASEB J. 2006 Dec;20(14):2624-6
pubmed: 17142801
J Cell Mol Med. 2014 Feb;18(2):231-41
pubmed: 24330074
Antioxid Redox Signal. 2016 Jul 20;25(3):119-46
pubmed: 26906267
Sci Rep. 2015 Aug 07;5:12936
pubmed: 26251179
Autophagy. 2018;14(8):1310-1322
pubmed: 29950142
Cancer Res. 2013 May 15;73(10):3097-108
pubmed: 23612120
Free Radic Biol Med. 2010 Apr 15;48(8):1051-63
pubmed: 20096777
Kidney Int. 2014 Aug;86(2):338-49
pubmed: 24717297
Mol Cell Biol. 2013 Jun;33(12):2402-12
pubmed: 23572560
Am J Transl Res. 2017 Nov 15;9(11):4756-4771
pubmed: 29218078
Free Radic Biol Med. 2011 Oct 15;51(8):1543-57
pubmed: 21839166
Oncotarget. 2018 Jun 19;9(47):28351-28363
pubmed: 29983865
PLoS One. 2012;7(10):e47299
pubmed: 23071780
Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1494-502
pubmed: 22442209
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19589-94
pubmed: 18048326
Ren Fail. 2019 Nov;41(1):750-761
pubmed: 31441362
Life Sci. 2018 Sep 1;208:79-86
pubmed: 30009822
Free Radic Biol Med. 2015 Nov;88(Pt B):337-349
pubmed: 26117320
Blood. 2012 Dec 20;120(26):5188-98
pubmed: 23077289
Lancet. 2014 May 24;383(9931):1831-43
pubmed: 24856028
N Engl J Med. 2011 Jul 28;365(4):327-36
pubmed: 21699484
Nat Rev Cancer. 2012 Jul 19;12(8):564-71
pubmed: 22810811
Free Radic Res. 2017 Jul-Aug;51(7-8):669-683
pubmed: 28750561
J Am Soc Nephrol. 2008 May;19(5):863-70
pubmed: 18287557
Carcinogenesis. 2013 May;34(5):1165-72
pubmed: 23492819
Am J Physiol Renal Physiol. 2009 Aug;297(2):F461-70
pubmed: 19458120
Free Radic Biol Med. 2019 Jul;138:33-42
pubmed: 31059771
Acta Pharmacol Sin. 2020 Mar;41(3):358-372
pubmed: 31645661
Cell Stress Chaperones. 2011 Jan;16(1):57-68
pubmed: 20734248
Nucleic Acids Res. 2010 Jan;38(3):778-88
pubmed: 19934254
Clin J Am Soc Nephrol. 2011 Aug;6(8):1903-11
pubmed: 21784819
Evid Based Complement Alternat Med. 2013;2013:636053
pubmed: 24348712
Toxicology. 2014 Apr 6;318:22-31
pubmed: 24530882
J Nephrol. 2015 Aug;28(4):495-501
pubmed: 25585822
Drugs. 2019 Jun;79(8):811-821
pubmed: 31004331