STIM Proteins: An Ever-Expanding Family.
CC1
CRAC
NMR
Orai
SOCE
STIM1
STIM2
isoforms
simulation
structure
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Dec 2020
31 Dec 2020
Historique:
received:
05
12
2020
revised:
20
12
2020
accepted:
26
12
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
7
4
2021
Statut:
epublish
Résumé
Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with Orai ion channels in the plasma membrane (PM), they form the molecular basis of the calcium release-activated calcium (CRAC) channel. An intracellular signaling pathway known as store-operated calcium entry (SOCE) is critically dependent on the CRAC channel. The SOCE pathway is activated by the ligand-induced depletion of the ER calcium store. STIM proteins, acting as calcium sensors, subsequently sense this depletion and activate Orai ion channels via direct physical interaction to allow the influx of calcium ions for store refilling and downstream signaling processes. This review article is dedicated to the latest advances in the field of STIM proteins. New results of ongoing investigations based on the recently published functional data as well as structural data from nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulations are reported and complemented with a discussion of the latest developments in the research of STIM protein isoforms and their differential functions in regulating SOCE.
Identifiants
pubmed: 33396497
pii: ijms22010378
doi: 10.3390/ijms22010378
pmc: PMC7795233
pii:
doi:
Substances chimiques
Calcium Channels
0
Stromal Interaction Molecules
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States
Organisme : Austrian Science Fund FWF
ID : W 1250
Pays : Austria
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