New Horizons in Hydrogels for Methotrexate Delivery.
cancer
drug delivery
hydrogels
methotrexate
psoriasis
rheumatoid arthritis
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
30 Dec 2020
30 Dec 2020
Historique:
received:
10
11
2020
revised:
14
12
2020
accepted:
21
12
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
6
1
2021
Statut:
epublish
Résumé
Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.
Identifiants
pubmed: 33396629
pii: gels7010002
doi: 10.3390/gels7010002
pmc: PMC7839000
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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