Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration.
Animals
Biomarkers
Cartilage, Articular
/ physiology
Cell Differentiation
Cell Proliferation
Cells, Cultured
Chondrogenesis
Disease Models, Animal
Fibroblast Growth Factor 2
/ metabolism
Gene Expression
Humans
Joint Capsule
/ cytology
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
/ cytology
Mice
Receptor, Fibroblast Growth Factor, Type 3
/ genetics
Regeneration
Spheroids, Cellular
basic fibroblast growth factor
cartilage regeneration
synovial mesenchymal stem cells
xenograft
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Dec 2020
30 Dec 2020
Historique:
received:
12
11
2020
revised:
25
12
2020
accepted:
25
12
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
2
4
2021
Statut:
epublish
Résumé
Synovial mesenchymal stem cell (SMSC) is the promising cell source of cartilage regeneration but has several issues to overcome such as limited cell proliferation and heterogeneity of cartilage regeneration ability. Previous reports demonstrated that basic fibroblast growth factor (bFGF) can promote proliferation and cartilage differentiation potential of MSCs in vitro, although no reports show its beneficial effect in vivo. The purpose of this study is to investigate the promoting effect of bFGF on cartilage regeneration using human SMSC in vivo. SMSCs were cultured with or without bFGF in a growth medium, and 2 × 10
Identifiants
pubmed: 33396695
pii: ijms22010300
doi: 10.3390/ijms22010300
pmc: PMC7796036
pii:
doi:
Substances chimiques
Biomarkers
0
Fibroblast Growth Factor 2
103107-01-3
Receptor, Fibroblast Growth Factor, Type 3
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Health and Labor Sciences Research
ID : 20K09410
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