Antimutagenic, Antiproliferative and Antioxidant Properties of Sea Grape Leaf Extract Fractions (Coccoloba uvifera L.).
Antimutagenic Agents
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Antioxidants
/ chemistry
Cell Proliferation
/ drug effects
Drug Screening Assays, Antitumor
Free Radicals
/ antagonists & inhibitors
Humans
Plant Extracts
/ chemistry
Plant Leaves
/ chemistry
Polygonaceae
/ chemistry
Salmonella typhimurium
/ drug effects
Sodium Azide
/ antagonists & inhibitors
Tumor Cells, Cultured
Coccoloba uvifera leaf
antimutagenicity
antioxidant
antiproliferation.
fractions
hexane extract
Journal
Anti-cancer agents in medicinal chemistry
ISSN: 1875-5992
Titre abrégé: Anticancer Agents Med Chem
Pays: Netherlands
ID NLM: 101265649
Informations de publication
Date de publication:
28 10 2021
28 10 2021
Historique:
received:
29
07
2020
revised:
02
11
2020
accepted:
09
11
2020
pubmed:
6
1
2021
medline:
21
1
2022
entrez:
5
1
2021
Statut:
ppublish
Résumé
Cancer is a disease characterized by the invasion and uncontrolled growth of cells. One of the best ways to minimize the harmful effects of mutagens is through the use of natural antimutagens. In this regard, the search for new antimutagens that act in the chemoprevention could represent a promising field in this area. In this study biological potential of 11 fractions from Coccoloba uvifera L. leaf hexane extract was evaluated by several in vitro tests. Leaves were lyophilized and hexane extraction was performed. The extract was fractionated by column chromatography with hexane, ethyl acetate, and methanol. The antimutagenic (Ames test), antiproliferative (MTT test), and antioxidant capacity (DPPH, ABTS, and ferrous ion chelation) of the fractions were evaluated. Fractions 4, 6, 8, and 9 have antimutagenic activity (against sodium azide in strain TA100), fraction 11 showed antiproliferative capacity (IC This study demonstrates, for the first time, the bioactivity of C. uvifera leaf as a new source of High Biological Value Compounds (HBVC), which can be of interest to the food and pharmaceutical industries.
Sections du résumé
BACKGROUND
Cancer is a disease characterized by the invasion and uncontrolled growth of cells. One of the best ways to minimize the harmful effects of mutagens is through the use of natural antimutagens. In this regard, the search for new antimutagens that act in the chemoprevention could represent a promising field in this area.
OBJECTIVE
In this study biological potential of 11 fractions from Coccoloba uvifera L. leaf hexane extract was evaluated by several in vitro tests.
METHODS
Leaves were lyophilized and hexane extraction was performed. The extract was fractionated by column chromatography with hexane, ethyl acetate, and methanol. The antimutagenic (Ames test), antiproliferative (MTT test), and antioxidant capacity (DPPH, ABTS, and ferrous ion chelation) of the fractions were evaluated.
RESULTS
Fractions 4, 6, 8, and 9 have antimutagenic activity (against sodium azide in strain TA100), fraction 11 showed antiproliferative capacity (IC
CONCLUSION
This study demonstrates, for the first time, the bioactivity of C. uvifera leaf as a new source of High Biological Value Compounds (HBVC), which can be of interest to the food and pharmaceutical industries.
Identifiants
pubmed: 33397268
pii: ACAMC-EPUB-113025
doi: 10.2174/1871520621999210104201242
doi:
Substances chimiques
Antimutagenic Agents
0
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Free Radicals
0
Plant Extracts
0
Sodium Azide
968JJ8C9DV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2250-2257Subventions
Organisme : Consejo Nacional de Ciencia y Tecnoligía (CONACyT, Mexico)
ID : 577058, CYTED THEMATIC NETWORK CODE 319RT0576
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.