Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in
Mycobacterium tuberculosis
Phenylalanyl-tRNA synthetase
aminoacyl tRNA synthetase
crystallography
high-throughput screening (HTS)
inhibition mechanism
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 Jan 2021
04 Jan 2021
Historique:
accepted:
04
01
2021
received:
27
10
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
6
1
2021
Statut:
aheadofprint
Résumé
Mycobacteria tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become a priority. The essential enzyme phenylalanyl-tRNA synthetase (PheRS) is an antibacterial drug target because of the large differences between bacterial and human PheRS counterparts. In a high-throughput screening of 2148 bioactive compounds, PF-3845, which is a known inhibitor of human fatty acid amide hydrolase (FAAH), was identified inhibiting Mtb PheRS at
Identifiants
pubmed: 33397709
pii: RA120.016477
doi: 10.1074/jbc.RA120.016477
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Published under license by The American Society for Biochemistry and Molecular Biology, Inc.