ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4.

Adenosine Diphosphate Ribose / chemistry Animals Binding Sites Chiroptera Coronavirus / enzymology Crystallography, X-Ray Hydrolysis Pyrophosphatases / chemistry Viral Nonstructural Proteins / chemistry
ADP-ribose coronavirus crystal structure macrodomain viral protein

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
12 01 2021
Historique:
entrez: 5 1 2021
pubmed: 6 1 2021
medline: 12 1 2021
Statut: ppublish

Résumé

Macrodomains are proteins that recognize and hydrolyze ADP ribose (ADPR) modifications of intracellular proteins. Macrodomains are implicated in viral genome replication and interference with host cell immune responses. They are important to the infectious cycle of

Identifiants

DOI: 10.1073/pnas.2004500118 PMID: 33397718 PMC: PMC7812796
pubmed: 33397718
pii: 2004500118
doi: 10.1073/pnas.2004500118
pmc: PMC7812796
pii:
doi:

Substances chimiques

Viral Nonstructural Proteins 0
Adenosine Diphosphate Ribose 20762-30-5
Pyrophosphatases EC 3.6.1.-
ADPribose pyrophosphatase EC 3.6.1.13

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE029007
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103403
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104135
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009110
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119456
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Robert G Hammond (RG)

Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294.
ORCID: 0000-0001-6934-9655

Norbert Schormann (N)

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
ORCID: 0000-0003-4215-7017

Robert Lyle McPherson (RL)

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
ORCID: 0000-0002-5922-889X

Anthony K L Leung (AKL)

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
ORCID: 0000-0001-5569-4036

Champion C S Deivanayagam (CCS)

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
ORCID: 0000-0003-2972-1824

Margaret A Johnson (MA)

Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294; margaret.a.johnson2@gmail.com.
ORCID: 0000-0002-4422-399X

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléoside diphosphate ose › Adénosine diphosphate ose › Adénosine diphosphate ribose › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Eucaryotes › Animaux › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Chiroptera › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Phénomènes chimiques › Hydrolyse › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Pyrophosphatases › ADP-ribose and analogues bound to the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › ADP-ribose and analogues bound to the...