Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
received:
03
09
2018
accepted:
19
11
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
15
1
2021
Statut:
epublish
Résumé
Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.
Identifiants
pubmed: 33397977
doi: 10.1038/s41467-020-20301-1
pii: 10.1038/s41467-020-20301-1
pmc: PMC7782689
doi:
Substances chimiques
Glucagon-Like Peptide 1
89750-14-1
Glucose
IY9XDZ35W2
1-Methyl-3-isobutylxanthine
TBT296U68M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110Références
Endocr Rev. 1999 Dec;20(6):876-913
pubmed: 10605628
Front Neuroendocrinol. 2010 Jan;31(1):44-60
pubmed: 19896496
Am J Physiol. 1994 Sep;267(3 Pt 1):G423-32
pubmed: 7943240
Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1449-54
pubmed: 11004015
Diabetes. 1981 Oct;30(10):879-82
pubmed: 7024024
Obes Surg. 2014 Dec;24(12):2145-51
pubmed: 24972684
Brain Res. 2010 Jul 16;1344:124-33
pubmed: 20452329
Diabetologia. 1968 Jan;4(1):56-67
pubmed: 5741526
Scand J Gastroenterol. 1998 Aug;33(8):828-32
pubmed: 9754730
Am J Med. 2009 Mar;122(3):248-256.e5
pubmed: 19272486
Gastroenterology. 2011 Sep;141(3):950-8
pubmed: 21699789
Gut. 2000 May;46(5):622-31
pubmed: 10764704
Am J Clin Nutr. 1994 Sep;60(3):307-11
pubmed: 8074058
Gastroenterology. 2016 Feb;150(2):454-64.e9
pubmed: 26481855
J Cell Biol. 1969 Mar;40(3):692-715
pubmed: 5765761
Nature. 2016 Mar 3;531(7592):53-8
pubmed: 26935695
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8641-5
pubmed: 1326760
Nat Cell Biol. 2017 Jul;19(7):774-786
pubmed: 28581476
Am J Physiol. 1996 Nov;271(5 Pt 1):E808-13
pubmed: 8944665
J Endocrinol. 2011 Oct;211(1):99-106
pubmed: 21795304
Regul Pept. 2008 Apr 10;147(1-3):29-32
pubmed: 18281111
Horm Metab Res. 1977 Jan;9(1):37-9
pubmed: 321317
Diabetes Care. 2013 Aug;36 Suppl 2:S145-8
pubmed: 23882039
Regul Pept. 2005 Jun 15;128(2):125-34
pubmed: 15780432
Z Gastroenterol. 1996 Mar;34(3):159-66
pubmed: 8650968
Histochemistry. 1976 Nov 19;50(1):33-7
pubmed: 794042
Mol Endocrinol. 2014 Jun;28(6):860-71
pubmed: 24766140
Cell Metab. 2017 Apr 4;25(4):927-934.e3
pubmed: 28325479
Eur J Pharmacol. 1995 Feb 15;288(3):319-27
pubmed: 7774676
Diabetes. 2019 May;68(5):1062-1072
pubmed: 30733330
Diabetes Care. 2015 Jun;38(6):1123-9
pubmed: 25784665
J Clin Endocrinol Metab. 2019 Dec 1;104(12):6403-6416
pubmed: 31276156
J Clin Invest. 2017 Dec 1;127(12):4217-4227
pubmed: 29202475
N Engl J Med. 2004 Dec 23;351(26):2683-93
pubmed: 15616203
J Clin Endocrinol Metab. 2010 Jan;95(1):215-21
pubmed: 19892837
Obes Surg. 2019 Apr;29(4):1343-1351
pubmed: 30684171
Science. 2013 Jul 26;341(6144):406-10
pubmed: 23888041
Physiol Rev. 2007 Oct;87(4):1409-39
pubmed: 17928588
Eur J Clin Invest. 1992 Apr;22(4):283-91
pubmed: 1499644
PLoS One. 2015 Mar 30;10(3):e0121414
pubmed: 25822172
Int J Obes Relat Metab Disord. 2000 Jul;24(7):899-905
pubmed: 10918538
N Engl J Med. 2012 Apr 26;366(17):1567-76
pubmed: 22449319
Nat Rev Endocrinol. 2009 May;5(5):262-9
pubmed: 19444259
Endocrinology. 2012 Jul;153(7):3054-65
pubmed: 22685263
Stem Cells. 2003;21(3):322-36
pubmed: 12743327
Endocrinology. 1999 Apr;140(4):1687-94
pubmed: 10098504
J Clin Endocrinol Metab. 1983 Apr;56(4):729-32
pubmed: 6687598
J Clin Endocrinol Metab. 1999 Jul;84(7):2513-7
pubmed: 10404829
Diabetologia. 2005 May;48(5):967-75
pubmed: 15830188
N Engl J Med. 2012 Apr 26;366(17):1577-85
pubmed: 22449317