Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
Animals
Antibodies, Viral
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Ferrets
/ immunology
Lung
/ immunology
RNA, Viral
/ isolation & purification
SARS-CoV-2
/ genetics
Virus Replication
/ drug effects
Virus Shedding
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
received:
23
05
2020
accepted:
30
11
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
14
1
2021
Statut:
epublish
Résumé
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model. After a high (5 × 10
Identifiants
pubmed: 33398055
doi: 10.1038/s41467-020-20439-y
pii: 10.1038/s41467-020-20439-y
pmc: PMC7782478
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
81Subventions
Organisme : NIMHD NIH HHS
ID : P20 MD006899
Pays : United States
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