Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19.
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
21 Dec 2020
21 Dec 2020
Historique:
pubmed:
6
1
2021
medline:
6
1
2021
entrez:
5
1
2021
Statut:
epublish
Résumé
A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequencing of 1,934 COVID-19 cases (713 with severe and 1,221 with mild disease) and 15,251 ancestry-matched population controls across four independent COVID-19 biobanks. We then tested if rare pLOF variants in these 13 genes were associated with severe COVID-19. We identified only one rare pLOF mutation across these genes amongst 713 cases with severe COVID-19 and observed no enrichment of pLOFs in severe cases compared to population controls or mild COVID-19 cases. We find no evidence of association of rare loss-of-function variants in the proposed 13 candidate genes with severe COVID-19 outcomes.
Identifiants
pubmed: 33398295
doi: 10.1101/2020.12.18.20248226
pmc: PMC7781338
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Commentaires et corrections
Type : UpdateIn
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