Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review).
Wnt family member 5a
periodontium
periodontal homeostasis
periodontitis
periodontal regeneration
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
02
09
2020
accepted:
25
11
2020
entrez:
5
1
2021
pubmed:
6
1
2021
medline:
6
5
2021
Statut:
ppublish
Résumé
The periodontium is a highly dynamic microenvironment constantly adapting to changing external conditions. In the processes of periodontal tissue formation and remodeling, certain molecules may serve an essential role in maintaining periodontal homeostasis. Wnt family member 5a (Wnt5a), as a member of the Wnt family, has been identified to have extensive biological roles in development and disease, predominantly through the non‑canonical Wnt signaling pathway or through interplay with the canonical Wnt signaling pathway. An increasing number of studies has also demonstrated that it serves crucial roles in periodontal tissues. Wnt5a participates in the development of periodontal tissues, maintains a non‑mineralized state of periodontal ligament, and regulates bone homeostasis. In addition, Wnt5a is involved in the pathogenesis of periodontitis. Recently, it has been shown to serve a positive role in the regeneration of integrated periodontal complex. The present review article focuses on recent research studies of Wnt5a and its functions in development, maintenance, and pathological disorders of periodontal tissues, as well as its potential effect on periodontal regeneration.
Identifiants
pubmed: 33398377
doi: 10.3892/mmr.2020.11806
pmc: PMC7821221
pii: 167
doi:
pii:
Substances chimiques
WNT5A protein, human
0
Wnt-5a Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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