A cell-based drug delivery platform for treating central nervous system inflammation.

Animals Cell Proliferation / drug effects Drug Delivery Systems / methods Drug Liberation Encephalomyelitis, Autoimmune, Experimental / blood Enzyme Inhibitors / administration & dosage Female Humans Immunity / drug effects Indoles / administration & dosage Maleimides / administration & dosage Mesenchymal Stem Cells / drug effects Mice Mice, Inbred C57BL Multiple Sclerosis / blood T-Lymphocytes / drug effects Tissue Distribution Transplantation, Heterologous / methods Treatment Outcome
Drug delivery Mesenchymal stem cells Multiple sclerosis Ro-31-8425

Journal

Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370

Informations de publication

Date de publication:
05 2021
Historique:
received: 16 06 2020
accepted: 29 10 2020
revised: 22 10 2020
pubmed: 6 1 2021
medline: 29 1 2022
entrez: 5 1 2021
Statut: ppublish

Résumé

Mesenchymal stem cells (MSCs) are promising candidates for the development of cell-based drug delivery systems for autoimmune inflammatory diseases, such as multiple sclerosis (MS). Here, we investigated the effect of Ro-31-8425, an ATP-competitive kinase inhibitor, on the therapeutic properties of MSCs. Upon a simple pretreatment procedure, MSCs spontaneously took up and then gradually released significant amounts of Ro-31-8425. Ro-31-8425 (free or released by MSCs) suppressed the proliferation of CD4

Identifiants

DOI: 10.1007/s00109-020-02003-9 PMID: 33398468 PMC: PMC8292974
pubmed: 33398468
doi: 10.1007/s00109-020-02003-9
pii: 10.1007/s00109-020-02003-9
pmc: PMC8292974
mid: NIHMS1720293
doi:

Substances chimiques

Enzyme Inhibitors 0
Indoles 0
Maleimides 0
Ro 31-8425 131848-97-0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

663-671

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL095722
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102807
Pays : United States

Références

Am J Stem Cells. 2013 Jun 30;2(2):95-107
pubmed: 23862098
J Control Release. 2014 Feb 28;176:123-132
pubmed: 24374002
PLoS One. 2010 Mar 05;5(3):e9478
pubmed: 20221429
Biochem Soc Trans. 2014 Dec;42(6):1524-8
pubmed: 25399564
Cell. 2015 Sep 10;162(6):1338-52
pubmed: 26359987
Immunity. 2012 Aug 24;37(2):249-63
pubmed: 22884314
Nat Med. 1999 Jan;5(1):42-8
pubmed: 9883838
Sci Rep. 2014 Apr 10;4:4645
pubmed: 24717973
Nat Immunol. 2005 Dec;6(12):1182-90
pubmed: 16369557
Arch Neurol. 2010 Oct;67(10):1187-94
pubmed: 20937945
Int Immunopharmacol. 2010 Dec;10(12):1496-500
pubmed: 20619384
Mult Scler. 2010 Mar;16(3):342-50
pubmed: 20106943
J Neurol Sci. 2013 Oct 15;333(1-2):43-9
pubmed: 23294498
N Engl J Med. 2012 Sep 20;367(12):1098-107
pubmed: 22992073
Annu Rev Pathol. 2011;6:457-78
pubmed: 21073342
J Clin Invest. 2004 Mar;113(6):924-32
pubmed: 15067325
Immunology. 2013 Mar;138(3):183-9
pubmed: 23190340
Nano Lett. 2012 Aug 8;12(8):4131-9
pubmed: 22769232
Curr Stem Cell Res Ther. 2011 Mar;6(1):69-72
pubmed: 20955153
J Neuroimmunol. 2013 Mar 15;256(1-2):43-8
pubmed: 23385082
Blood. 2003 May 1;101(9):3722-9
pubmed: 12506037
Cell Rep. 2015 Mar 3;10(8):1261-1268
pubmed: 25732817
J Neuroimmunol. 1992 Jun;38(3):229-40
pubmed: 1376328
Nanoscale Res Lett. 2017 Dec;12(1):202
pubmed: 28314369
Nature. 2008 May 1;453(7191):65-71
pubmed: 18362915
Curr Pharm Des. 2012;18(30):4725-46
pubmed: 22830352
Biochem J. 1993 Sep 1;294 ( Pt 2):335-7
pubmed: 8373348
J Clin Invest. 2012 Apr;122(4):1180-8
pubmed: 22466660
Lancet. 2008 Oct 25;372(9648):1502-17
pubmed: 18970977
PLoS One. 2011;6(12):e28321
pubmed: 22205945
Cell Stem Cell. 2012 Mar 2;10(3):244-58
pubmed: 22385653
N Engl J Med. 2006 Mar 2;354(9):899-910
pubmed: 16510744
Curr Opin Immunol. 2010 Dec;22(6):768-74
pubmed: 21093239
Stem Cell Reports. 2016 Jun 14;6(6):926-939
pubmed: 27264972
Cell Signal. 1997 Jan;9(1):53-7
pubmed: 9067630
Nat Med. 2015 Jun;21(6):638-46
pubmed: 26005855
J Exp Med. 2003 May 5;197(9):1073-81
pubmed: 12732654
Brain Pathol. 2000 Jul;10(3):402-18
pubmed: 10885659
Drugs Exp Clin Res. 1991;17(8):389-93
pubmed: 1822831
Ann Neurol. 2013 Sep;74(3):317-27
pubmed: 23955638
Ann Neurol. 1996 Mar;39(3):285-94
pubmed: 8602746
J Neurosci Res. 2006 Aug 15;84(3):587-95
pubmed: 16773650
Curr Top Med Chem. 2009;9(7):640-54
pubmed: 19689371
Transplantation. 2003 Feb 15;75(3):389-97
pubmed: 12589164
Glia. 2009 Aug 15;57(11):1192-203
pubmed: 19191336
Nat Med. 2016 Jun;22(6):586-97
pubmed: 27158906
Gastroenterology. 2008 Feb;134(2):459-69
pubmed: 18155708
J Med Chem. 2013 Mar 14;56(5):1799-810
pubmed: 23398373
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Biomaterials. 2016 Jun;91:140-150
pubmed: 27019026
Mult Scler. 2013 Jan;19(1):31-45
pubmed: 22383231

Auteurs

Oren Levy (O)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Veit Rothhammer (V)

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Ivan Mascanfroni (I)

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Zhixiang Tong (Z)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Rui Kuai (R)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.
Centre of Excellence for Biomedicine, Brigham and Women's Hospital, Boston, MA, USA.

Michael De Biasio (M)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Qingping Wang (Q)

Department of Drug Metabolism and Pharmacokinetics, Sanofi R&D, Waltham, MA, USA.

Tahir Majid (T)

Global Research Program and Portfolio Management, Sanofi-Genzyme, Cambridge, MA, USA.

Christelle Perrault (C)

Sanofi R&D, In Vitro Pharmacology, Integrated Drug Discovery, Centre de Recherche Vitry-Alfortville, Vitry-Sur-Seine, France.

Ada Yeste (A)

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Jessica E Kenison (JE)

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Helia Safaee (H)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Juliet Musabeyezu (J)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Martina Heinelt (M)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Yuka Milton (Y)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Heidi Kuang (H)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

Haoyue Lan (H)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

William Siders (W)

Genzyme R&D, Neuroimmunology Research, Framingham, MA, USA.

Marie-Christine Multon (MC)

Sanofi R&D, Translational Sciences, Centre de Recherche Vitry-Alfortville, Vitry-Sur-Seine, France.

Jonathan Rothblatt (J)

Sanofi R&D, Biologics Research, Cambridge, MA, 02139, USA.

Salam Massadeh (S)

Developmental Medicine Department, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

Manal Alaamery (M)

Developmental Medicine Department, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

Ali H Alhasan (AH)

Centre of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
National Center of Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

Francisco J Quintana (FJ)

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@bwh.harvard.edu.
Centre of Excellence for Biomedicine, Brigham and Women's Hospital, Boston, MA, USA. fquintana@bwh.harvard.edu.
The Broad Institute of Harvard and MIT, Cambridge, MA, USA. fquintana@bwh.harvard.edu.
ORCID: 0000-0001-8156-0736

Jeffrey M Karp (JM)

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA. jeffkarp@mit.edu.
Centre of Excellence for Biomedicine, Brigham and Women's Hospital, Boston, MA, USA. jeffkarp@mit.edu.
The Broad Institute of Harvard and MIT, Cambridge, MA, USA. jeffkarp@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A cell-based drug delivery platform for...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › A cell-based drug delivery platform for...
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questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › A cell-based drug delivery platform for...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › A cell-based drug delivery platform for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › A cell-based drug delivery platform for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A cell-based drug delivery platform for...
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questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Maléimides › A cell-based drug delivery platform for...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › A cell-based drug delivery platform for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A cell-based drug delivery platform for...
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questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › A cell-based drug delivery platform for...
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