Frozen-thawed embryo transfer is an independent risk factor for third stage of labor complications.
Conception
Frozen-thawed embryo transfer
IVF
Third stage
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
03
08
2020
accepted:
01
12
2020
pubmed:
6
1
2021
medline:
11
11
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Third stage of labor complications are more prevalent following singleton vaginal deliveries of gestations conceived through in vitro fertilization (IVF) and fresh embryo transfer. This study aimed to evaluate these complications in pregnancies conceived through frozen-thawed embryo transfer (FET), in which endometrial preparation differs from fresh cycles. A cohort study of all singleton pregnancies conceived through IVF-FET who delivered vaginally at a tertiary medical center during 2007-2017. The study group consisted of 88 IVF-FET gestations (cases) that were matched to 176 spontaneous pregnancies based on age, gravidity, parity and gestational week at delivery (controls). The association between mode of conception and third stage of labor complication rate was examined. Baseline characteristics were similar between groups, except for a lower prevalence of induction of labor in the control group (23.3% vs. 36.3%, p = 0.03). The rate of post-partum hemorrhage (PPH), manual lysis and revision of the uterine cavity were all higher in pregnancies conceived through IVF-FET versus spontaneously (13.6% vs. 5.7%, p = 0.018; 17% vs. 2.3%, p < 0.001; and 21.6% vs. 6.8%, p < 0.001, respectively). Multivariate analysis adjusting for age, previous cesarean section, induction of labor, neonatal weight and use of analgesia demonstrated that deliveries following IVF-FET were independently associated with an increased risk for third stage of labor complications (estimated OR = 3.45, p = 0.0002). IVF-FET is an independent risk factor for PPH, need for manual lysis and revision of the uterine cavity. Precautionary measures should be undertaken in the third stage in deliveries following IVF-FET, even if no other risk factors are present.
Identifiants
pubmed: 33398506
doi: 10.1007/s00404-020-05935-2
pii: 10.1007/s00404-020-05935-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-537Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
Références
De Geyter C, Calhaz-Jorge C, Kupka MS, Wyns C, Mocanu E, Motrenko T, Scaravelli G, Smeenk J, Vidakovic S, Goossens V (2020) The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE) ART in Europe, 2015: results generated from European registries by ESHRE. Hum Reprod Open. https://doi.org/10.1093/hropen/hoz038
doi: 10.1093/hropen/hoz038
pubmed: 32995563
pmcid: 7508022
Assisted reproductive technology, national summery report (2015). https://www.cdc.gov/art/pdf/2015-report/ART-2015-National-Summary-Report.pdf . Accessed 10 May 2020
Singh B, Reschke L, Segars J, Baker VL (2020) Frozen-thawed embryo transfer: the potential importance of the corpus luteum in preventing obstetrical complications. Fertil Steril 113(2):252–257. https://doi.org/10.1016/j.fertnstert.2019.12.007
doi: 10.1016/j.fertnstert.2019.12.007
pubmed: 32106972
pmcid: 7380557
Roque M, Valle M, Sampaio M, Geber S (2018) Obstetric outcomes after fresh versus frozen-thawed embryo transfers: a systematic review and meta-analysis. JBRA Assist Reprod. 22(3):253–260. https://doi.org/10.5935/1518-0557.20180049
doi: 10.5935/1518-0557.20180049
pubmed: 29782139
pmcid: 6106638
Wei D, Liu JY, Sun Y, Shi Y, Zhang B, Liu JQ et al (2019) Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet 393(10178):1310–1318. https://doi.org/10.1016/S0140-6736(18)32843-5
doi: 10.1016/S0140-6736(18)32843-5
pubmed: 30827784
Sha T, Yin X, Cheng W, Massey IY (2018) Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril 109:330–342.e9
doi: 10.1016/j.fertnstert.2017.10.019
Ginstrom EE, Wennerholm UB, Khatibi A, Petzold M, Bergh C (2019) Neonatal and maternal outcome after frozen embryo transfer: Increased risks in programmed cycles. Am J Obstet Gynecol 221:126.e1–126.e18
doi: 10.1016/j.ajog.2019.03.010
Steer P, Flint C (1999) ABC of labour care: physiology and management of normal labour. Br Med J 318:793–796
doi: 10.1136/bmj.318.7186.793
Wise A, Clark V (2008) Strategies to manage major obstetric haemorrhage. Curr Opin Anaesthesiol 21:281–287
doi: 10.1097/ACO.0b013e3282f8e257
American College of Obstetricians and Gynecologists (2006) ACOG Practice Bulletin: Clinical Management Guidelines for Obstetrician-Gynecologists Number 76, October 2006: postpartum hemorrhage. Obstet Gynecol 108:1039–1047
doi: 10.1097/00006250-200610000-00046
WHO Guidelines Approved by the Guidelines Review Committee (2007) Pregnancy, childbirth, postpartum and newborn care: a guide for essential practice, 2nd edn. World Health Organization, Geneva
Wertheimer A, Melamed S, Ashwal E, Sapir O, Oron G, Ben-Haroush A, Shochat T, Wiznitzer A, Shufaro Y (2020) Complications of the third stage of labor are more prevalent in IVF pregnancies [published online ahead of print, 2020 Feb 23]. J Matern Fetal Neonatal Med 5:1–5. https://doi.org/10.1080/14767058.2020.1730797
doi: 10.1080/14767058.2020.1730797
Esh-Broder E, Ariel I, Abas-Bashir N, Bdolah Y, Hochner Celnikier D (2011) Placenta accreta is associated with IVF pregnancies: a retrospective chart review. BJOG 118:1084–1089
doi: 10.1111/j.1471-0528.2011.02976.x
Iacovelli A, Liberati M, Khalil A, Timor-Trisch I, Leombroni M, Buca D et al (2018) Risk factors for abnormally invasive placenta: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 22:1–11
Healy DL, Breheny S, Halliday J, Jaques A, Rushford D, Garrett C, Talbot JM, Baker HWG (2010) Prevalence and risk factors for obstetric haemorrhage in 6730 singleton births after assisted reproductive technology in Victoria Australia. Hum Reprod 25:265–274
doi: 10.1093/humrep/dep376
Hayashi M, Nakai A, Satoh S, Matsuda Y (2012) Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used. Fertil Steril 98:922–928
doi: 10.1016/j.fertnstert.2012.05.049
Nyfløt LT, Sandven I, Oldereid NB, Stray-Pedersen B, Vangen S (2017) Assisted reproductive technology and severe postpartum haemorrhage: a case-control study. BJOG 124:1198–1205
doi: 10.1111/1471-0528.14471
Wikland M, Hardarson T, Hillensjö T, Westin C, Westlander G, Wood M, Wennerholm UB (2010) Obstetric outcomes after transfer of vitrified blastocysts. Hum Reprod 25(7):1699–1707. https://doi.org/10.1093/humrep/deq117
doi: 10.1093/humrep/deq117
pubmed: 20472913
Aziz MM, Guirguis G, Maratto S, Benito C, Forman EJ (2016) Is there an association between assisted reproductive technologies and time and complications of the third stage of labor? Arch Gynecol Obstet 293:1193–1196
doi: 10.1007/s00404-015-3943-3
Saito K, Kuwahara A, Ishikawa T, Morisaki N, Miyado M, Miyado K et al (2019) Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Hum Reprod 34(8):1567–1575. https://doi.org/10.1093/humrep/dez079
doi: 10.1093/humrep/dez079
pubmed: 31299081
Wang Z, Liu H, Song H, Li X, Jiang J, Sheng Y, Shi Y (2020) Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles. Front Med (Lausanne) 7:104. https://doi.org/10.3389/fmed.2020.00104
doi: 10.3389/fmed.2020.00104
Pereira N, Elias RT, Christos PJ, Petrini AC, Hancock K, Lekovich JP, Rosenwaks Z (2017) Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer. Hum Reprod 32(7):1410–1417. https://doi.org/10.1093/humrep/dex095
doi: 10.1093/humrep/dex095
pubmed: 28505290
pmcid: 6251696
Jing S, Li X, Zhang S, Gong F, Lu G, Lin G (2019) The risk of placenta previa and cesarean section associated with a thin endometrial thickness: a retrospective study of 5251 singleton births during frozen embryo transfer in China. Arch Gynecol Obstet 300(5):1227–1237. https://doi.org/10.1007/s00404-019-05295-6
doi: 10.1007/s00404-019-05295-6
pubmed: 31552485
Nakamura Y, Yaguchi C, Itoh H, Sakamoto R, Kimura T, Furuta N, et al (2015) Morphologic characteristics of the placental basal plate in in vitro fertilization pregnancies: a possible association with the amount of bleeding in delivery. Hum Pathol 46(8):1171–1179. https://doi.org/10.1016/j.humpath.2015.04.007
doi: 10.1016/j.humpath.2015.04.007
pubmed: 26058728
Lee B, Koeppel AF, Wang ET, Gonzalez TL, Sun T, Kroener L et al (2019) Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies. Fertil Steril 111(3):535–546. https://doi.org/10.1016/j.fertnstert.2018.11.005
doi: 10.1016/j.fertnstert.2018.11.005
pubmed: 30611556
pmcid: 7156023
Blanks AM, Zhao ZH, Shmygol A, Bru-Mercier G, Astle S, Thornton S (2007) Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium. J Physiol 581(Pt 3):915–926. https://doi.org/10.1113/jphysiol.2007.132126
doi: 10.1113/jphysiol.2007.132126
pubmed: 17446221
pmcid: 1976399