The association between hidradenitis suppurativa and male and female infertility: A population-based study.
Adult
Age Factors
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus
/ epidemiology
Female
Hidradenitis Suppurativa
/ epidemiology
Humans
Infertility, Female
/ epidemiology
Infertility, Male
/ epidemiology
Israel
/ epidemiology
Male
Marital Status
Middle Aged
Obesity
/ epidemiology
Retrospective Studies
Smoking
/ epidemiology
Social Class
cohort
female infertility
hidradenitis suppurativa (HS)
male infertility
Journal
The Australasian journal of dermatology
ISSN: 1440-0960
Titre abrégé: Australas J Dermatol
Pays: Australia
ID NLM: 0135232
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
13
10
2020
accepted:
15
11
2020
pubmed:
6
1
2021
medline:
15
12
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Endocrine and metabolic associations have been recently reported in patients with hidradenitis suppurativa (HS); however, fertility was only rarely investigated in women and not at all in men. To evaluate the association of HS with male and female infertility. A cross-sectional, matched controlled, population-based study was designed. The association between HS and male and female infertility was evaluated in patients with HS (n = 4191) and age- and gender-matched controls (n = 20 941), while utilising the Clalit Health Services databases, the largest community-based health maintenance organisation in Israel. Hidradenitis suppurativa was associated with infertility in males and females over all reproductive-age groups, especially among individuals aged 36-45 years (OR 4.50, 95%CI 2.55-7.93, P < 0.001), and in female patients (OR 3.10, 95%CI 2.57-3.74, P < 0.001). After adjustment for demographic and clinical factors, the association remained significant only in females (OR 1.26 95%CI 1.04-1.55, P < 0.05). Patients with HS are at increased risk of infertility, particularly females and patients in the 36- to 45-year age group. Physicians should take the additional physiological and psychological burden of infertility among HS patients into account, primarily among female patients at procreative age.
Sections du résumé
BACKGROUND
BACKGROUND
Endocrine and metabolic associations have been recently reported in patients with hidradenitis suppurativa (HS); however, fertility was only rarely investigated in women and not at all in men.
OBJECTIVE
OBJECTIVE
To evaluate the association of HS with male and female infertility.
METHODS
METHODS
A cross-sectional, matched controlled, population-based study was designed. The association between HS and male and female infertility was evaluated in patients with HS (n = 4191) and age- and gender-matched controls (n = 20 941), while utilising the Clalit Health Services databases, the largest community-based health maintenance organisation in Israel.
RESULTS
RESULTS
Hidradenitis suppurativa was associated with infertility in males and females over all reproductive-age groups, especially among individuals aged 36-45 years (OR 4.50, 95%CI 2.55-7.93, P < 0.001), and in female patients (OR 3.10, 95%CI 2.57-3.74, P < 0.001). After adjustment for demographic and clinical factors, the association remained significant only in females (OR 1.26 95%CI 1.04-1.55, P < 0.05).
CONCLUSION
CONCLUSIONS
Patients with HS are at increased risk of infertility, particularly females and patients in the 36- to 45-year age group. Physicians should take the additional physiological and psychological burden of infertility among HS patients into account, primarily among female patients at procreative age.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e223-e227Informations de copyright
© 2021 The Australasian College of Dermatologists.
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