Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children.
Journal
Journal of pediatric gastroenterology and nutrition
ISSN: 1536-4801
Titre abrégé: J Pediatr Gastroenterol Nutr
Pays: United States
ID NLM: 8211545
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
pubmed:
6
1
2021
medline:
10
7
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
We sought to evaluate the relevance of pediatric dairy fat recommendations for children at risk for nonalcoholic fatty liver disease (NAFLD) by studying the association between dairy fat intake and the amount of liver fat. The effects of dairy fat may be mediated by odd chain fatty acids (OCFA), such as pentadecanoic acid (C15:0), and monomethyl branched chain fatty acids (BCFA), such as iso-heptadecanoic acid (iso-C17:0). Therefore, we also evaluated the association between plasma levels of OCFA and BCFA with the amount of liver fat. Observational, cross-sectional, community-based sample of 237 children ages 8 to 17. Dairy fat intake was assessed by 3 24-hour dietary recalls. Plasma fatty acids were measured by gas chromatography-mass spectrometry. Main outcome was hepatic steatosis measured by whole liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). Median dairy fat intake was 10.6 grams/day (range 0.0--44.5 g/day). Median liver MRI-PDFF was 4.5% (range 0.9%-45.1%). Dairy fat intake was inversely correlated with liver MRI-PDFF (r = -0.162; P = .012). In multivariable log linear regression, plasma C15:0 and iso-C17:0 were inverse predictors of liver MRI-PDFF (B = -0.247, P = 0.048; and B = -0.234, P = 0.009). Dairy fat intake, plasma C15:0, and plasma iso-C17:0 were inversely correlated with hepatic steatosis in children. These hypothesis-generating findings should be tested through clinical trials to better inform dietary guidelines.
Identifiants
pubmed: 33399331
doi: 10.1097/MPG.0000000000003040
pii: 00005176-202104000-00024
pmc: PMC8842839
mid: NIHMS1773095
doi:
Substances chimiques
Fatty Acids
0
pentadecanoic acid
CCW02D961F
margaric acid
V987Y9OZ8L
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e90-e96Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000100
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Informations de copyright
Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Déclaration de conflit d'intérêts
M.C.S., M.W., E.S., N.P.G., K.P.N., E.L.Y., C.B., J.D., C.K., J.A.G., B.A.B., J.M.G., N.M., A.S., C.M.M. report no conflicts of interest. M.S.M. consults for Bracco, Kowa, Median, Merge Healthcare, Novo Nordisk, Quantitative Insights; and has grant funding from Gilead and Guerbet. C.B.S. received grant funding from Bayer, GE, Philips, and Siemens; consults for AMRA, Boehringer, and Guerbet; is on the speaker's bureau for Resoundant and has lab service agreements with Gilead, ICON, Intercept, Shire, and Synageva. J.B,S. received grant funding from Galmed, Intercept, and Genfit.
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