Low-Intensity Pulsed Ultrasound as a Potential Adjuvant Therapy to Promote Spinal Fusion: Systematic Review and Meta-analysis of the Available Data.
low-intensity pulsed ultrasound
nonunion
pseudarthrosis
spinal fusion
Journal
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
ISSN: 1550-9613
Titre abrégé: J Ultrasound Med
Pays: England
ID NLM: 8211547
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
27
10
2020
received:
11
09
2020
accepted:
14
11
2020
pubmed:
6
1
2021
medline:
22
9
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Despite extensive research, nonunion continues to affect a nontrivial proportion of patients undergoing spinal fusion. Recently, preclinical studies have suggested that low-intensity pulsed ultrasound (LIPUS) may increase rates of spinal fusion. In this study, we summarized the available in vivo literature evaluating the effect of LIPUS on spinal fusion and performed a meta-analysis of the available data to estimate the degree to which LIPUS may mediate higher fusion rates. Across 13 preclinical studies, LIPUS was associated with a 9-fold increase in the odds of successful spinal fusion. Future studies are necessary to establish the benefit of LIPUS on spinal fusion in clinical populations.
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2005-2017Subventions
Organisme : NIA NIH HHS
ID : F30AG063445 (Cottrill)
Pays : United States
Organisme : NIA NIH HHS
ID : F30AG063445 (Cottrill)
Pays : United States
Informations de copyright
© 2020 American Institute of Ultrasound in Medicine.
Références
Rajaee SS, Bae HW, Kanim LE, Delamarter RB. Spinal fusion in the United States: analysis of trends from 1998 to 2008. Spine (Phila Pa 1976) 2012; 37:67-76.
Weiss AJ, Elixhauser A, Andrews RM. Characteristics of operating room procedures in U.S. hospitals, 2011: statistical brief #170. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville, MD: Agency for Healthcare Research and Quality; 2014; 1-7.
Tsutsumimoto T, Shimogata M, Yoshimura Y, Misawa H. Union versus nonunion after posterolateral lumbar fusion: a comparison of long-term surgical outcomes in patients with degenerative lumbar spondylolisthesis. Eur Spine J 2008; 17:1107-1112.
Noshchenko A, Lindley EM, Burger EL, Cain CM, Patel VV. What is the clinical relevance of radiographic nonunion after single-level lumbar interbody arthrodesis in degenerative disc sisease? A meta-analysis of the YODA project database. Spine (Phila Pa 1976) 2016; 41:9-17.
Scheer JK, Oh T, Smith JS, et al. Development of a validated computer-based preoperative predictive model for pseudarthrosis with 91% accuracy in 336 adult spinal deformity patients. Neurosurg Focus 2018; 45:E11.
Miller EK, Neuman BJ, Jain A, et al. An assessment of frailty as a tool for risk stratification in adult spinal deformity surgery. Neurosurg Focus 2017; 43:E3.
Cottrill E, Ahmed AK, Lessing N, et al. Investigational growth factors utilized in animal models of spinal fusion: systematic review. World J Orthop 2019; 10:176-191.
Cottrill E, Pennington Z, Lankipalle N, et al. The effect of bioactive glasses on spinal fusion: A cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data. J Clin Neurosci 2020; 78:34-46.
Cottrill E, Lazzari J, Pennington Z, et al. Oxysterols as promising small molecules for bone tissue engineering: systematic review. World J Orthop 2020; 11:328-344.
Cottrill E, Premananthan C, Pennington Z, et al. Radiographic and clinical outcomes of silicate-substituted calcium phosphate (SiCaP) bone grafts in spinal fusion: systematic review and meta-analysis. J Clin Neurosci 2020; 81:353-366.
Cottrill E, Pennington Z, Ahmed AK, et al. The effect of electrical stimulation therapies on spinal fusion: a cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data [published online ahead of print October 8, 2019]. J Neurosurg Spine 1-21. https://doi.org/10.3171/2019.5.SPINE19465. Epub ahead of print. PMID: 31593923.
McAnany SJ, Baird EO, Overley SC, Kim JS, Qureshi SA, Anderson PA. A meta-analysis of the clinical and fusion results following treatment of symptomatic cervical pseudarthrosis. Global Spine J 2015; 5:148-155.
Chun DS, Baker KC, Hsu WK. Lumbar pseudarthrosis: a review of current diagnosis and treatment. Neurosurg Focus 2015; 39:E10.
Zhou XY, Xu XM, Wu SY, et al. Low-intensity pulsed ultrasound promotes spinal fusion and enhances migration and proliferation of MG63s through sonic hedgehog signaling pathway. Bone 2018; 110:47-57.
Kaproth-Joslin KA, Nicola R, Dogra VS. The history of US: from bats and boats to the bedside and beyond-RSNA centennial article. Radiographics 2015; 35:960-970.
Pohlman R, Richter R, Parow E. Über die Ausbreitung und Absorption des Ultraschalls im menschlichen Gewebe und seine therapeutische Wirkung an Ischias und Plexusneuralgie. Dtsch Med Wochenschr 1939; 65:251-254.
Ardan NI Jr, Janes JM, Herrick JF. Changes in bone after exposure to ultrasonic energy. Minn Med 1954; 37:415-420.
Baker KG, Robertson VJ, Duck FA. A review of therapeutic ultrasound: biophysical effects. Phys Ther 2001; 81:1351-1358.
Maintz G. Animal experiments in the study of the effect of ultrasonic waves on bone regeneration. Strahlentherapie 1950; 82:631-638.
Schortinghuis J, Stegenga B, Raghoebar GM, de Bont LG. Ultrasound stimulation of maxillofacial bone healing. Crit Rev Oral Biol Med 2003; 14:63-74.
Xavier C, Duarte L. Ultrasonic stimulation of bone callus: clinical applications. Rev Bras Orthop 1983; 18:73-80.
Harrison A, Lin S, Pounder N, Mikuni-Takagaki Y. Mode and mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair. Ultrasonics 2016; 70:45-52.
Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am 1994; 76:26-34.
Nolte PA, van der Krans A, Patka P, Janssen IM, Ryaby JP, Albers GH. Low-intensity pulsed ultrasound in the treatment of nonunions. J Trauma 2001; 51:693-703.
Padilla F, Puts R, Vico L, Raum K. Stimulation of bone repair with ultrasound: a review of the possible mechanic effects. Ultrasonics 2014; 54:1125-1145.
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol 2014; 14:43.
Hooijmans CR, Hlavica M, Schuler FAF, et al. Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis. Sci Rep 2019; 9:822.
Macleod MR, Fisher M, O'Collins V, et al. Good laboratory practice: preventing introduction of bias at the bench. Stroke 2009; 40:e50-e52.
Wang J, Li JW, Chen L. Effect of low-intensity pulsed ultrasound on posterolateral lumbar fusion of rabbit. Asian Pac J Trop Med 2015; 8:68-72.
Freeman MF, Tukey JW. Transformations related to the angular and the square root. Ann Math Stat 1950; 21:607-611.
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7:177-188.
Clopper CJ, Pearson ES. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika 1934; 26:404-413.
Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ 2004; 328:1490.
Fawzy El-Sayed KM, Ahmed GM, Abouauf EA, Schwendicke F. Stem/progenitor cell-mediated pulpal tissue regeneration: a systematic review and meta-analysis. Int Endod J 2019; 52:1573-1585.
Glazer PA, Heilmann MR, Lotz JC, Bradford DS. Use of ultrasound in spinal arthrodesis: a rabbit model. Spine (Phila Pa 1976) 1998; 23:1142-1148.
Cook SD, Salkeld SL, Patron LP, Ryaby JP, Whitecloud TS. Low-intensity pulsed ultrasound improves spinal fusion. Spine J 2001; 1:246-254.
Aynaci O, Onder C, Piskin A, Ozoran Y. The effect of ultrasound on the healing of muscle-pediculated bone graft in spinal fusion. Spine (Phila Pa 1976) 2002; 27:1531-1535.
Wang XY, Guo X, Cheng JC, Mi YL, Lai PY. Involvement of calcitonin gene-related peptide innervation in the promoting effect of low-intensity pulsed ultrasound on spinal fusion without decortication. Spine (Phila Pa 1976) 2010; 35:E1539-E1545.
Zhuo X, Lü H, Xu D, et al. Effects of low-intensity pulsed ultrasound stimulation on porous hydroxyapatite blocks for posterolateral fusion of lumbar spine in rabbits. Trans Nonferrous Met Soc Chin 2010; 20:1921-1927.
Hui CF, Chan CW, Yeung HY, et al. Low-intensity pulsed ultrasound enhances posterior spinal fusion implanted with mesenchymal stem cells-calcium phosphate composite without bone grafting. Spine (Phila Pa 1976) 2011; 36:1010-1016.
Liao JC, Chen WJ, Chen LH, Lai PL, Keorochana G. Low-intensity pulsed ultrasound enhances healing of laminectomy chip bone grafts on spinal fusion: a model of posterolateral intertransverse fusion in rabbits. J Trauma 2011; 70:863-869.
Liao JC, Chen WJ, Niu CC, Chen LH. Effects of low-intensity pulsed ultrasound on spinal pseudarthrosis created by nicotine administration: a model of lumbar posterolateral pseudarthrosis in rabbits. J Ultrasound Med 2015; 34:1043-1050.
Xu X, Wang F, Yang Y, et al. LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone. Sci Rep 2016; 6:20116.
Zhou XY, Xu XM, Wu SY, et al. Low-intensity pulsed ultrasound-induced spinal fusion is coupled with enhanced calcitonin gene-related peptide expression in rat model. Ultrasound Med Biol 2017; 43:1486-1493.
Zhang ZC, Yang YL, Li B, et al. Low-intensity pulsed ultrasound promotes spinal fusion by regulating macrophage polarization. Biomed Pharmacother 2019; 120:109499.
Bioventus, LLC. Exogen patient brochure. Exogen website; 2017. http://www.exogen.com/wp-content/uploads/SMK-002044_Exogen-Patient-Brochure-ENG-Yogo.pdf.
Coords M, Breitbart E, Paglia D, et al. The effects of low-intensity pulsed ultrasound upon diabetic fracture healing. J Orthop Res 2011; 29:181-188.
Huang W, Hasegawa T, Imai Y, Takeda D, Akashi M, Komori T. Low-intensity pulsed ultrasound enhances bone morphogenetic protein expression of human mandibular fracture haematoma-derived cells. Int J Oral Maxillofac Surg 2015; 44:929-935.
Kumagai K, Takeuchi R, Ishikawa H, et al. Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors. J Orthop Res 2012; 30:1516-1521.
Lai CH, Chen SC, Chiu LH, et al. Effects of low-intensity pulsed ultrasound, dexamethasone/TGF-beta1 and/or BMP-2 on the transcriptional expression of genes in human mesenchymal stem cells: chondrogenic vs osteogenic differentiation. Ultrasound Med Biol 2010; 36:1022-1033.
Mahoney CM, Morgan MR, Harrison A, Humphries MJ, Bass MD. Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. J Biol Chem 2009; 284:8898-8909.
Naruse K, Sekiya H, Harada Y, et al. Prolonged endochondral bone healing in senescence is shortened by low-intensity pulsed ultrasound in a manner dependent on COX-2. Ultrasound Med Biol 2010; 36:1098-1108.
Otsuru S, Tamai K, Yamazaki T, Yoshikawa H, Kaneda Y. Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. Stem Cells 2008; 26:223-234.
Reher P, Harris M, Whiteman M, Hai HK, Meghji S. Ultrasound stimulates nitric oxide and prostaglandin E2 production by human osteoblasts. Bone 2002; 31:236-241.
Simon AM, Manigrasso MB, O'Connor JP. Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 2002; 17:963-976.
Takayama T, Suzuki N, Ikeda K, et al. Low-intensity pulsed ultrasound stimulates osteogenic differentiation in ROS 17/2.8 cells. Life Sci 2007; 80:965-971.
Tang CH, Yang RS, Huang TH, et al. Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts. Mol Pharmacol 2006; 69:2047-2057.
Tassinary JAF, Lunardelli A, Basso BS, et al. Low-intensity pulsed ultrasound (LIPUS) stimulates mineralization of MC3T3-E1 cells through calcium and phosphate uptake. Ultrasonics 2018; 84:290-295.
Wang FS, Kuo YR, Wang CJ, et al. Nitric oxide mediates ultrasound-induced hypoxia-inducible factor-1alpha activation and vascular endothelial growth factor-A expression in human osteoblasts. Bone 2004; 35:114-123.
Xu XM, Xu TM, Wei YB, et al. Low-intensity pulsed ultrasound treatment accelerates angiogenesis by activating YAP/TAZ in human umbilical vein endothelial cells. Ultrasound Med Biol 2018; 44:2655-2661.
Leung KS, Cheung WH, Zhang C, Lee KM, Lo HK. Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells. Clin Orthop Relat Res 2004; 418:253-259.
McKenzie JA, Maschhoff C, Liu X, Migotsky N, Silva MJ, Gardner MJ. Activation of hedgehog signaling by systemic agonist improves fracture healing in aged mice. J Orthop Res 2019; 37:51-59.