Central nervous system delivery of molecules across the blood-brain barrier.
Blood-brain barrier
Brain diseases
Central nervous system drug delivery
Cyclodextrins
Nanoparticles
PLGA
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
21
10
2020
revised:
15
12
2020
accepted:
23
12
2020
pubmed:
6
1
2021
medline:
16
11
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
Therapies targeting neurological conditions such as Alzheimer's or Parkinson's diseases are hampered by the presence of the blood-brain barrier (BBB). During the last decades, several approaches have been developed to overcome the BBB, such as the use of nanoparticles (NPs) based on biomaterials, or alternative methods to open the BBB. In this review, we briefly highlight these strategies and the most recent advances in this field. Limitations and advantages of each approach are discussed. Combination of several methods such as functionalized NPs targeting the receptor-mediated transcytosis system with the use of magnetic resonance imaging-guided focused ultrasound (FUS) might be a promising strategy to develop theranostic tools as well as to safely deliver therapeutic molecules, such as drugs, neurotrophic factors or antibodies within the brain parenchyma.
Identifiants
pubmed: 33400964
pii: S0197-0186(20)30343-0
doi: 10.1016/j.neuint.2020.104952
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104952Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.