Novel curcumin analog (cis-trans curcumin) as ligand to adenosine receptors A
5'-N-Ethylcarboxamidoadenosine (PubChem CID: 4400)
Adenosine
Adenosine receptor A(2A)
Adenosine receptor A(2B)
Chronic pain
Cis-Trans curcumin (PubChem CID: 969516)
Curcumin
Curcumin (PubChem CID: 969516)
G(stimulatory)
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
19
11
2020
revised:
22
12
2020
accepted:
23
12
2020
pubmed:
6
1
2021
medline:
7
1
2022
entrez:
5
1
2021
Statut:
ppublish
Résumé
All four of the adenosine receptor (AR) subtypes mediate pain and have been targeted by pharmacologists to generate new therapeutics for chronic pain. The vanilloid phytochemicals, which include curcumin, capsaicin, and gingerol, have been shown to alleviate pain. However, there is little to no literature on the interaction of vanilloid phytochemicals with ARs. In this study, photochemical methods were used to generate a novel isomer of curcumin (cis-trans curcumin or CTCUR), and the interactions of both curcumin and CTCUR with the two G
Identifiants
pubmed: 33401004
pii: S1043-6618(20)31718-7
doi: 10.1016/j.phrs.2020.105410
pmc: PMC7979524
mid: NIHMS1662291
pii:
doi:
Substances chimiques
Ligands
0
Receptor, Adenosine A2A
0
Receptor, Adenosine A2B
0
Cyclic AMP
E0399OZS9N
Curcumin
IT942ZTH98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105410Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115458
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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