S100A9-Imaging Enables Estimation of Early Therapy-Mediated Changes in the Inflammatory Tumor Microenvironment.
MRP8/MRP14
calprotectin
molecular imaging
tumor microenvironment
tumor-associated monocytes
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
03 Jan 2021
03 Jan 2021
Historique:
received:
03
12
2020
revised:
24
12
2020
accepted:
28
12
2020
entrez:
6
1
2021
pubmed:
7
1
2021
medline:
7
1
2021
Statut:
epublish
Résumé
(1) Background: The prognosis of cancer is dependent on immune cells in the tumor microenvironment (TME). The protein S100A9 is an essential regulator of the TME, associated with poor prognosis. In this study, we evaluated early therapy effects on the TME in syngeneic murine breast cancer via S100A9-specific in vivo imaging. (2) Methods: Murine 4T1 cells were implanted orthotopically in female BALB/c mice (
Identifiants
pubmed: 33401528
pii: biomedicines9010029
doi: 10.3390/biomedicines9010029
pmc: PMC7823872
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : CiM Cluster of Excellence, PP-2017-01
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