Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review.
coenzyme Q10
feverfew
ginkgolide B
magnesium
melatonin
migraine
polyunsaturated fatty acids
riboflavin
vitamin D
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
03 Jan 2021
03 Jan 2021
Historique:
received:
21
11
2020
revised:
25
12
2020
accepted:
31
12
2020
entrez:
6
1
2021
pubmed:
7
1
2021
medline:
7
1
2021
Statut:
epublish
Résumé
Complementary and integrative medicines (CIMs) are increasingly used as a preventive antimigraine therapy. In this review, we aimed to summarize the evidence for the efficacy and safety of eight CIMs (riboflavin, coenzyme Q10, magnesium, melatonin, polyunsaturated fatty acids, and combination therapy of feverfew, vitamin D, and ginkgolide B) in pediatric migraine prevention. The level of evidence for riboflavin was relatively high; it was investigated by many studies with five/seven studies demonstrating its efficacy. Five studies investigated the use of melatonin, with one reporting negative results. There was insufficient evidence on the effectiveness of coenzyme Q10, magnesium, and polyunsaturated fatty acids. Combination therapy showed positive potential; however, reports on the individual antimigraine effects of the CIMs were lacking. A definitive conclusion was not reached regarding the specific integrative drugs clinicians should choose for pediatric migraines, owing to low-quality evidence and a limited number of studies. Integrative medications are becoming more common for pediatric migraine prevention as they do not produce serious side effects, and underlying research data suggest their efficacy in preventing migraine. Additional studies are warranted to confirm the role of CIMs in treating patients with migraines.
Identifiants
pubmed: 33401551
pii: jcm10010138
doi: 10.3390/jcm10010138
pmc: PMC7794736
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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