The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors.
Intrinsically photosensitive retinal ganglion cells
Melanopsin
Myopia
Pupil
Refractive error
Journal
Journal of optometry
ISSN: 1989-1342
Titre abrégé: J Optom
Pays: Spain
ID NLM: 101482903
Informations de publication
Date de publication:
Historique:
received:
15
09
2020
revised:
21
11
2020
accepted:
01
12
2020
pubmed:
7
1
2021
medline:
4
5
2022
entrez:
6
1
2021
Statut:
ppublish
Résumé
The intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults with various refractive errors using a custom-made optical system. PIPR was measured on myopic (-3.50 ± 1.82 D, n = 20) and non-myopic (+0.28 ± 0.23 D, n = 19) participants (mean age, 23.36 ± 3.06 years). The right eye was dilated and presented with long-wavelength (red, 625 nm, 3.68 × 10 For most subjects, the 6 s and 30 s PIPR were significantly lower (p < 0.001), and the early and late AUC were significantly larger for 1 s blue light compared to red light (p < 0.001), suggesting a strong ipRGC response. The 5 s blue stimulation induced a slightly stronger melanopsin response, compared to 1 s stimulation with the same wavelength. However, none of the PIPR metrics were different between myopes and non-myopes for either stimulus duration (p > 0.05). We confirm previous research that there is no effect of refractive error on the PIPR.
Identifiants
pubmed: 33402286
pii: S1888-4296(20)30123-0
doi: 10.1016/j.optom.2020.12.001
pmc: PMC9068560
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-121Informations de copyright
Copyright © 2020 Spanish General Council of Optometry. Published by Elsevier España, S.L.U. All rights reserved.
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