Bacteriospermia, extended spectrum beta lactamase producing Gram-negative bacteria and other factors associated with male infertility in Mwanza, Tanzania: a need of diagnostic bacteriology for management of male infertility.
Adult
Anti-Bacterial Agents
/ pharmacology
Cross-Sectional Studies
Gram-Negative Bacteria
/ drug effects
Gram-Negative Bacterial Infections
/ microbiology
Humans
Infertility, Male
/ epidemiology
Male
Semen
/ microbiology
Spermatozoa
/ microbiology
Tanzania
/ epidemiology
beta-Lactam Resistance
beta-Lactamases
/ metabolism
Mwanza
Tanzania
bacteriospermia
blaCTX-M
extended spectrum beta lactamase
male infertility
Journal
African health sciences
ISSN: 1729-0503
Titre abrégé: Afr Health Sci
Pays: Uganda
ID NLM: 101149451
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
6
1
2021
pubmed:
7
1
2021
medline:
13
2
2021
Statut:
ppublish
Résumé
Infections caused by Extended spectrum beta lactamase (ESBL) producing bacterial are global challenge. There is limited information on the magnitude of bacteriospermia, ESBL producing Gram-negative bacteria (GNB) causing bacteriospermia and factors associated with male infertility. This study determined magnitude of bacteriospermia, ESBL-GNB and other factors association with infertility among presumptive infertile men in Mwanza, Tanzania. A cross-sectional hospital-based study was conducted between May 2017 and July 2018 among 137 presumptive infertile men. Semen specimens were self-collected by masturbation into clean, sterile and none-spermicidal containers and processed following laboratory standard operating procedures (SOPs). Data analysis was done using STATA 13.0. Gram-negative bacteria were predominantly isolated (86.4%), of which 31.6% were ESBL producers. In a total 44 bacteria were isolated from semen culture. The One third of bacteriospermia is due to ESBL-producers with history of antibiotic use being protective factor for infertility. Abnormal spermatozoa morphology and poor spermatozoa forward motility independently predicted infertility.
Sections du résumé
BACKGROUND
BACKGROUND
Infections caused by Extended spectrum beta lactamase (ESBL) producing bacterial are global challenge. There is limited information on the magnitude of bacteriospermia, ESBL producing Gram-negative bacteria (GNB) causing bacteriospermia and factors associated with male infertility. This study determined magnitude of bacteriospermia, ESBL-GNB and other factors association with infertility among presumptive infertile men in Mwanza, Tanzania.
METHODS
METHODS
A cross-sectional hospital-based study was conducted between May 2017 and July 2018 among 137 presumptive infertile men. Semen specimens were self-collected by masturbation into clean, sterile and none-spermicidal containers and processed following laboratory standard operating procedures (SOPs). Data analysis was done using STATA 13.0.
RESULTS
RESULTS
Gram-negative bacteria were predominantly isolated (86.4%), of which 31.6% were ESBL producers. In a total 44 bacteria were isolated from semen culture. The
CONCLUSION
CONCLUSIONS
One third of bacteriospermia is due to ESBL-producers with history of antibiotic use being protective factor for infertility. Abnormal spermatozoa morphology and poor spermatozoa forward motility independently predicted infertility.
Identifiants
pubmed: 33402887
doi: 10.4314/ahs.v20i1.4
pii: jAFHS.v20.i1.pg4
pmc: PMC7750055
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-13Informations de copyright
© 2020 Silago V et al.
Références
BMC Emerg Med. 2016 Oct 21;16(1):41
pubmed: 27769180
Hum Reprod Update. 2010 May-Jun;16(3):231-45
pubmed: 19934213
BMJ. 2016 Feb 08;352:h6420
pubmed: 26858245
Urol Clin North Am. 2008 May;35(2):137-46, vii
pubmed: 18423235
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:90-103
pubmed: 18154532
BMC Infect Dis. 2013 Oct 07;13:466
pubmed: 24099282
PLoS One. 2017 Sep 12;12(9):e0184592
pubmed: 28898269
BMC Pediatr. 2010 Jun 04;10:39
pubmed: 20525358
Eur Respir J. 2008 Nov;32(5):1141-3
pubmed: 18978131
AIDS Res Treat. 2015;2015:103874
pubmed: 25793123
Clin Microbiol Rev. 1995 Oct;8(4):557-84
pubmed: 8665470
Hum Reprod. 2002 Feb;17(2):362-9
pubmed: 11821279
Andrologia. 2003 Oct;35(5):283-7
pubmed: 14535856
BMC Infect Dis. 2009 Jun 17;9:97
pubmed: 19534775
Andrologia. 2008 Apr;40(2):72-5
pubmed: 18336453
Front Microbiol. 2016 Dec 01;7:1862
pubmed: 27990135
Int J Med Microbiol. 2018 Oct;308(7):803-811
pubmed: 29980372
Oman Med J. 2013 Mar;28(2):116-20
pubmed: 23599880
Zh Mikrobiol Epidemiol Immunobiol. 2000 Mar-Apr;(2):106-10
pubmed: 10808590
Interdiscip Perspect Infect Dis. 2016;2016:2614692
pubmed: 26880908
Interdiscip Perspect Infect Dis. 2014;2014:819896
pubmed: 24790598