Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
Adenosine Diphosphate
/ metabolism
Adenosine Triphosphatases
/ chemistry
Adenosine Triphosphate
/ metabolism
Amino Acid Sequence
Binding, Competitive
Chromatin
/ genetics
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
/ chemistry
DNA Helicases
/ chemistry
Humans
Hydrolysis
Mi-2 Nucleosome Remodeling and Deacetylase Complex
/ chemistry
Mutation
Nucleosomes
/ genetics
Protein Binding
Protein Domains
Sequence Homology, Amino Acid
Substrate Specificity
ADP
ATPase
chromatin
competitive inhibitor
remodeling enzyme
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
19
11
2020
received:
14
07
2020
accepted:
04
01
2021
pubmed:
7
1
2021
medline:
3
8
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Chromatin remodelers use the energy of ATP hydrolysis to regulate chromatin dynamics. Their impact for development and disease requires strict enzymatic control. Here, we address the differential regulability of the ATPase domain of hSNF2H and hCHD3, exhibiting similar substrate affinities and enzymatic activities. Both enzymes are comparably strongly inhibited in their ATP hydrolysis activity by the competitive ATPase inhibitor ADP. However, the nucleosome remodeling activity of SNF2H is more strongly affected than that of CHD3. Beside ADP, also IP
Substances chimiques
Chromatin
0
Chromosomal Proteins, Non-Histone
0
Nucleosomes
0
Adenosine Diphosphate
61D2G4IYVH
Adenosine Triphosphate
8L70Q75FXE
Mi-2 Nucleosome Remodeling and Deacetylase Complex
EC 3.5.1.98
Adenosine Triphosphatases
EC 3.6.1.-
SMARCA5 protein, human
EC 3.6.1.-
DNA Helicases
EC 3.6.4.-
CHD3 protein, human
EC 3.6.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4000-4023Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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