MIND and Mediterranean Diets Associated with Later Onset of Parkinson's Disease.
MIND diet
Parkinson's disease
mediterranean diet
sex differences
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
13
11
2020
received:
11
07
2020
accepted:
01
12
2020
pubmed:
7
1
2021
medline:
20
5
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
The MIND diet has been linked with prevention of Alzheimer's disease and cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). The objective of the present study was to determine whether MIND diet adherence is associated with the age of Parkinson's disease onset in a manner superior to that of the Mediterranean diet. Food Frequency Questionnaires from 167 participants with PD and 119 controls were scored for MIND and 2 versions of Mediterranean diet adherence. Scores were compared between sex and disease subgroups, and PD diet adherence was correlated with age at onset using univariate and multivariate linear models. The female subgroup adhered more closely to the MIND diet than the male subgroup, and diet scores were not modified by disease status. Later age of onset correlated most strongly with MIND diet adherence in the female subgroup, corresponding to differences of up to 17.4 years (P < 0.001) between low and high dietary tertiles. Greek Mediterranean adherence was also significantly associated with later PD onset across all models (P = 0.05-0.03). Conversely, only Greek Mediterranean diet adherence remained correlated with later onset across all models in men, with differences of up to 8.4 years (P = 0.002). This cross-sectional study found a strong correlation between age of onset of PD and dietary habits, suggesting that nutritional strategies may be an effective tool to delay PD onset. Further studies may help to elucidate potential nutrition-related sex-specific pathophysiological mechanisms and differential prevalence rates in PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Sections du résumé
BACKGROUND
The MIND diet has been linked with prevention of Alzheimer's disease and cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). The objective of the present study was to determine whether MIND diet adherence is associated with the age of Parkinson's disease onset in a manner superior to that of the Mediterranean diet.
METHODS
Food Frequency Questionnaires from 167 participants with PD and 119 controls were scored for MIND and 2 versions of Mediterranean diet adherence. Scores were compared between sex and disease subgroups, and PD diet adherence was correlated with age at onset using univariate and multivariate linear models.
RESULTS
The female subgroup adhered more closely to the MIND diet than the male subgroup, and diet scores were not modified by disease status. Later age of onset correlated most strongly with MIND diet adherence in the female subgroup, corresponding to differences of up to 17.4 years (P < 0.001) between low and high dietary tertiles. Greek Mediterranean adherence was also significantly associated with later PD onset across all models (P = 0.05-0.03). Conversely, only Greek Mediterranean diet adherence remained correlated with later onset across all models in men, with differences of up to 8.4 years (P = 0.002).
CONCLUSIONS
This cross-sectional study found a strong correlation between age of onset of PD and dietary habits, suggesting that nutritional strategies may be an effective tool to delay PD onset. Further studies may help to elucidate potential nutrition-related sex-specific pathophysiological mechanisms and differential prevalence rates in PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Identifiants
pubmed: 33404118
doi: 10.1002/mds.28464
pmc: PMC8248352
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
977-984Subventions
Organisme : CIHR
ID : FDN-159935
Pays : Canada
Informations de copyright
© 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Références
Prev Med. 2007 Apr;44(4):335-40
pubmed: 17350085
Br J Nutr. 2012 Oct 28;108(8):1428-34
pubmed: 22221517
Mov Disord. 2017 Nov;32(11):1631-1636
pubmed: 28881039
BMJ. 2008 Sep 11;337:a1344
pubmed: 18786971
Alzheimers Dement. 2015 Sep;11(9):1007-14
pubmed: 25681666
Sci Rep. 2016 Feb 24;6:22135
pubmed: 26906725
Nutr J. 2015 May 12;14:46
pubmed: 25962728
BMJ Open. 2014 Mar 27;4(3):e004503
pubmed: 24674997
Neurology. 2009 Feb 3;72(5):432-8
pubmed: 19188574
World J Psychiatry. 2016 Mar 22;6(1):54-65
pubmed: 27014598
Lancet Neurol. 2019 Nov;18(11):998-1008
pubmed: 31521532
Mov Disord. 2018 Dec;33(12):1945-1950
pubmed: 30376184
Mov Disord. 2020 Jul;35(7):1208-1217
pubmed: 32357258
N Engl J Med. 2003 Jun 26;348(26):2599-608
pubmed: 12826634
Lancet. 2015 Jun 6;385(9984):2255-63
pubmed: 25771249
Carcinogenesis. 2019 May 14;40(3):448-460
pubmed: 30874285
J Clin Epidemiol. 1993 Feb;46(2):153-62
pubmed: 8437031
Public Health Nutr. 2001 Jun;4(3):847-58
pubmed: 11415493
Mov Disord. 2012 May;27(6):771-4
pubmed: 22314772
J Affect Disord. 2019 Sep 1;256:96-102
pubmed: 31170621
J Nutr Health Aging. 2018;22(10):1211-1215
pubmed: 30498828
Lancet. 2015 Aug 29;386(9996):896-912
pubmed: 25904081
Behav Brain Res. 2017 Jan 15;317:332-339
pubmed: 27702635
Mov Disord. 2019 Jan;34(1):48-57
pubmed: 30306634
Mov Disord. 2019 Dec;34(12):1891-1900
pubmed: 31584222
Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):262-296
pubmed: 27127938
Front Neurol. 2019 Feb 26;10:148
pubmed: 30863359
Alzheimers Dement. 2019 Apr;15(4):581-589
pubmed: 30826160
Am J Clin Nutr. 2007 Nov;86(5):1486-94
pubmed: 17991663
Arch Gerontol Geriatr. 2015 Nov-Dec;61(3):510-6
pubmed: 26272284
Alzheimers Dement. 2015 Sep;11(9):1015-22
pubmed: 26086182
Nutr Neurosci. 2020 May 22;:1-8
pubmed: 32441566