Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?
Adenosquamous carcinoma
Cervical cancer
Gastric-type adenocarcinoma
HPV-independent cancer
Squamous differentiation
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
04
11
2020
accepted:
14
12
2020
revised:
29
11
2020
pubmed:
7
1
2021
medline:
10
9
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Gastric-type adenocarcinoma (GAS) of the cervix is a human papilloma virus (HPV)-independent, aggressive, and chemo-resistant adenocarcinoma. However, although the histopathological features of GAS have been extensively investigated, squamous differentiation has not been mentioned. This study aimed to elucidate the frequency of GAS with squamous differentiation and describe their clinicopathological characteristics. We retrospectively evaluated 78 patients with GAS (n = 13) and adenosquamous carcinoma (n = 65) diagnosed between 2000 and 2020. Two patients with GAS with squamous differentiation were identified. Both tumors showed advanced stage (pT2bN1) and had predominant GAS and merged squamous cell carcinoma components without p16-block positivity and HPV DNA. Gastric-type adenocarcinoma in situ was confirmed in both cases. Some cases of GAS could show squamous differentiation mimicking the usual, HPV-associated, adenosquamous carcinoma. GAS with squamous differentiation is recognized as an HPV-independent cancer.
Identifiants
pubmed: 33404855
doi: 10.1007/s00428-020-02997-0
pii: 10.1007/s00428-020-02997-0
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-412Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
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