How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson's disease.
Autophagy
Dopaminergic neurons
GABP
Latent virus
Microcompetition
Mitochondrial dysfunction
Parkinson’s disease
Susbstantia nigra
p300/cbp
α synuclein
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
18
03
2020
accepted:
19
11
2020
revised:
19
10
2020
pubmed:
7
1
2021
medline:
15
12
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
The cause of most Parkinson's disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction and excess α synuclein aggregation, and eventually, Parkinson's disease.
Identifiants
pubmed: 33405201
doi: 10.1007/s13365-020-00929-x
pii: 10.1007/s13365-020-00929-x
doi:
Substances chimiques
alpha-Synuclein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-57Références
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