Clinical Implications of Minimal Residual Disease Detection in Infants With
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
ISSN: 1527-7755
Titre abrégé: J Clin Oncol
Pays: United States
ID NLM: 8309333
Informations de publication
Date de publication:
20 02 2021
20 02 2021
Historique:
pubmed:
7
1
2021
medline:
16
9
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of MRD was measured in 249 infants by DNA-based polymerase chain reaction of rearranged EOI MRD levels predicted outcome with 6-year disease-free survival (DFS) of 60.2% (95% CI, 43.2 to 73.6), 45.0% (95% CI, 28.3 to 53.1), and 33.8% (95% CI, 23.8 to 44.1) for infants with negative, intermediate, and high EOI MRD levels, respectively ( This study provides support for the idea that induction therapy selects patients for subsequent therapy; infants with high EOI MRD may benefit from AML-like consolidation (DFS 45.9%
Identifiants
pubmed: 33405950
doi: 10.1200/JCO.20.02333
pmc: PMC8196086
doi:
Banques de données
EudraCT
['2005-004599-19']
ClinicalTrials.gov
['NCT00550992']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
652-662Commentaires et corrections
Type : ErratumIn
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