Serum response factor, a novel early diagnostic biomarker of acute kidney injury.
acute kidney injury
biomarker
serum response factor
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
05 01 2021
05 01 2021
Historique:
received:
15
06
2020
accepted:
31
10
2020
pubmed:
7
1
2021
medline:
11
5
2021
entrez:
6
1
2021
Statut:
ppublish
Résumé
Studies have shown that serum response factor (SRF) is increased in chronic kidney injury, such as diabetic nephropathy, hyperuricemic nephropathy and renal cell carcinoma. The objective is to explore the early diagnostic value of SRF in acute kidney injury (AKI). AKI-related microarray data were analyzed, and the expression and location of SRF were investigated in the early phase of AKI. Bioinformatics results demonstrated that SRF was dramatically elevated 2-4 h after ischemia/reperfusion (I/R) in mouse renal tissue. In I/R rats, SRF was mostly expressed and located in renal tubular epithelial cells (TECs). SRF started to increase at 1 h, peaked at 3-9 h and started to decrease at 12 h after I/R. The areas under the ROC curve of renal SRF mRNA, renal SRF protein, urinary SRF, serum SRF and serum creatinine (Scr) were 87.9%, 83.0%, 81.3%, 78.8%, 68.8%, respectively. SRF is remarkably upregulated in early (before 24 h) AKI and can replace Scr as a potential new early diagnostic biomarker of AKI.
Identifiants
pubmed: 33406503
pii: 202381
doi: 10.18632/aging.202381
pmc: PMC7880358
doi:
Substances chimiques
Serum Response Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2885-2894Références
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