Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
IL-2R signaling
Regulatory T cells
Treg heterogeneity
scRNA sequencing
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
21
04
2020
accepted:
14
11
2020
pubmed:
8
1
2021
medline:
28
12
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under noninflammatory conditions, Cd25
Identifiants
pubmed: 33408345
doi: 10.1038/s41423-020-00599-z
pii: 10.1038/s41423-020-00599-z
pmc: PMC8027001
doi:
Substances chimiques
Forkhead Transcription Factors
0
Il2ra protein, mouse
0
Interleukin-2
0
Interleukin-2 Receptor alpha Subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
398-414Références
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