Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis.
Animals
Apoptosis
Biomarkers, Tumor
/ genetics
Cell Movement
Cell Proliferation
Colorectal Neoplasms
/ blood supply
Extracellular Matrix Proteins
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms
/ blood supply
Mice
Neovascularization, Pathologic
/ metabolism
Prognosis
Signal Transduction
Transforming Growth Factor beta
/ genetics
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
alternative TGFβ signaling
endothelial cells
liver metastases
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2020
accepted:
04
11
2020
entrez:
7
1
2021
pubmed:
8
1
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due to mutations in the receptors and/or downstream signaling molecules. TGFβ influences CRC cells only indirectly via stromal cells, such as cancer-associated fibroblasts. However, CRC cell ability to directly respond to TGFβ currently remains unexplored. This represents a missed opportunity for diagnostic and therapeutic interventions.
Identifiants
pubmed: 33408771
doi: 10.7150/thno.51507
pii: thnov11p1626
pmc: PMC7778592
doi:
Substances chimiques
Biomarkers, Tumor
0
Extracellular Matrix Proteins
0
Transforming Growth Factor beta
0
betaIG-H3 protein
148710-76-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1626-1640Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Curr Opin Oncol. 2018 Jan;30(1):45-53
pubmed: 29084000
Theranostics. 2019 Feb 20;9(5):1453-1473
pubmed: 30867843
J Pathol. 2007 Nov;213(3):257-65
pubmed: 17893910
Gastroenterology. 2015 Jun;148(7):1427-37.e8
pubmed: 25736321
Hepatology. 2014 Mar;59(3):924-34
pubmed: 23832580
EMBO J. 1994 Sep 15;13(18):4212-22
pubmed: 7925267
Genes Dev. 2008 Feb 1;22(3):308-21
pubmed: 18245446
Nat Protoc. 2010 Apr;5(4):739-43
pubmed: 20360768
J Clin Med. 2016 Jun 29;5(7):
pubmed: 27367735
Trends Biochem Sci. 2013 Dec;38(12):612-20
pubmed: 24239264
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
BMC Cancer. 2018 Jan 15;18(1):78
pubmed: 29334918
Nature. 2016 Jan 21;529(7586):298-306
pubmed: 26791720
Case Rep Gastrointest Med. 2015;2015:140616
pubmed: 25705527
Gut. 2017 Oct;66(10):1802-1810
pubmed: 27456153
N Engl J Med. 2001 Apr 19;344(16):1196-206
pubmed: 11309634
Cancer Cell. 2012 Mar 20;21(3):309-22
pubmed: 22439926
Cancer Res. 2009 Jan 1;69(1):37-44
pubmed: 19117985
J Clin Med. 2017 Jan 18;6(1):
pubmed: 28106769
J Natl Cancer Inst. 1998 Jul 1;90(13):1000-8
pubmed: 9665149
PLoS Biol. 2010 Jun 29;8(6):e1000412
pubmed: 20613859
Am J Pathol. 2001 Oct;159(4):1187-92
pubmed: 11583944
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Pharmacol Ther. 2015 Mar;147:22-31
pubmed: 25444759
Genes Dev. 1996 Oct 1;10(19):2462-77
pubmed: 8843198
Biochim Biophys Acta. 2013 Nov;1834(11):2396-407
pubmed: 23684732
Cancer Cell. 2012 Nov 13;22(5):571-84
pubmed: 23153532
Calcif Tissue Int. 2012 Jul;91(1):81-7
pubmed: 22644324
Cancer Res. 2001 Oct 1;61(19):6996-7001
pubmed: 11585723
Transl Oncol. 2019 Mar;12(3):475-484
pubmed: 30594036
Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20
pubmed: 17613544
Theranostics. 2020 Jan 16;10(5):2327-2341
pubmed: 32089745
Gastroenterology. 2017 Jan;152(1):36-52
pubmed: 27773809
Clin Exp Metastasis. 1989 Jan-Feb;7(1):55-68
pubmed: 2908828
Cancers (Basel). 2017 Sep 04;9(9):
pubmed: 28869579
DNA Cell Biol. 1992 Sep;11(7):511-22
pubmed: 1388724
Nat Rev Cancer. 2014 Sep;14(9):611-22
pubmed: 25118602
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3087-91
pubmed: 10077641
Cancer Res. 2016 Jun 15;76(12):3618-28
pubmed: 27197176
Cell. 2003 May 2;113(3):301-14
pubmed: 12732139