Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice.
Zika virus
diversity
transmission
Journal
Virus evolution
ISSN: 2057-1577
Titre abrégé: Virus Evol
Pays: England
ID NLM: 101664675
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
entrez:
7
1
2021
pubmed:
8
1
2021
medline:
8
1
2021
Statut:
epublish
Résumé
The fundamental basis of how arboviruses evolve in nature and what regulates the adaptive process remain unclear. To address this problem, we established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice to study the evolutionary characteristics of ZIKV infection. Using this system, we defined factors that influence the evolutionary landscape of ZIKV infection and show that transmission route and specific organ microenvironments impact viral diversity and defective viral genome production. In addition, we identified in mice the emergence of ZIKV mutants previously seen in natural infections, including variants present in currently circulating Asian and American strains, as well as mutations unique to the mouse infections. With these studies, we have established an insect-to-mouse transmission model to study ZIKV evolution
Identifiants
pubmed: 33408879
doi: 10.1093/ve/veaa092
pii: veaa092
pmc: PMC7772475
doi:
Types de publication
Journal Article
Langues
eng
Pagination
veaa092Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007180
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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