Efficacy of topical interventions for temporomandibular disorders compared to placebo or control therapy: a systematic review with meta-analysis.
Meta-analysis
Systematic Review
Temporomandibular Joint Disorders
Topical Administration
Visual Analog Scale
Journal
Journal of dental anesthesia and pain medicine
ISSN: 2383-9309
Titre abrégé: J Dent Anesth Pain Med
Pays: Korea (South)
ID NLM: 101690691
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
08
2020
revised:
23
10
2020
accepted:
23
11
2020
entrez:
7
1
2021
pubmed:
8
1
2021
medline:
8
1
2021
Statut:
ppublish
Résumé
This systematic review focused on the efficacy of topical products in reducing temporomandibular joint disorder (TMD)-associated pain, in comparison to placebo or control interventions. The EMBASE, Web of Science, Cochrane Library, and MEDLINE via PubMed databases were searched for randomized controlled trials (RCTs) using topical interventions in adults diagnosed with TMD. The pain intensity was the primary outcome, and other clinical findings were the secondary outcomes. The risk of bias was evaluated according to the Cochrane's handbook. The search up to February 7, 2020 identified a total of 496 unduplicated references. Nine RCTs with 355 adult patients diagnosed with TMD were included. The meta-analysis did not show a significant reduction in baseline pain intensity in the nonsteroidal anti-inflammatory drug (NSAIDs) group, when compared to the placebo group (P = 0.288). One study demonstrated a statistically significant pain score decrease for Theraflex-TMJ compared to placebo after 10 d of treatment (P = 0.003) and follow-up, 5 d after the last application (P = 0.027). Ping On reduced pain at 4 weeks of application (P < 0.001) but not after 7 d of application (P = 0.136). In one study, cannabidiol (CBD) significantly improved the pain intensity compared to placebo (P < 0.001). However, no differences were found with capsaicin in the two studies (P = 0.465). Evidence was of low quality because the studies were considered as having an unclear or a high risk of bias and a small number of studies were analyzed. The evidence is not sufficient to support the use of topical NSAIDs and capsaicin, and limited evidence was found for Threraflex-TMJ, bee venom, Ping On, and CBD, with only one study reporting for each. Additional studies are recommended to validate these results.
Identifiants
pubmed: 33409363
doi: 10.17245/jdapm.2020.20.6.337
pmc: PMC7783375
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
337-356Informations de copyright
Copyright © 2020 Journal of Dental Anesthesia and Pain Medicine.
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS: The authors have no conflicts of interest to declare.
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