Vitamin K in CKD Bone Disorders.
Bone fractures
CKD
Matrix Gla protein
Osteocalcin
Vitamin K
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
12
10
2020
accepted:
05
12
2020
pubmed:
8
1
2021
medline:
19
8
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
Vitamin K is principally known because it is involved in blood coagulation. Furthermore, epidemiological studies showed that its deficit was associated with increased fragility fractures, vascular calcification and mortality. There are two main types of vitamin K vitamers: Phylloquinone (or PK) and Menaquinones (MKn). Vitamin K acts both as coenzyme of y-glutamyl carboxylase (GGCX) transforming undercarboxylated in carboxylated vitamin K-dependent proteins (e.g., Osteocalcin and Matrix Gla Protein) and as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. It has been highlighted that the uremic state is a condition of greater vitamin K deficiency than the general population with resulting higher prevalence of bone fractures, vascular calcifications and mortality. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone health in CKD patients.
Identifiants
pubmed: 33409597
doi: 10.1007/s00223-020-00792-2
pii: 10.1007/s00223-020-00792-2
doi:
Substances chimiques
Osteocalcin
104982-03-8
Vitamin K
12001-79-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
476-485Références
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