Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis.
Aphthous stomatitis
Association
Meta-analysis
Zinc
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
22
09
2020
accepted:
24
11
2020
pubmed:
8
1
2021
medline:
26
1
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
The present meta-analysis sought to investigate the potential association between zinc levels and recurrent aphthous stomatitis (RAS). A comprehensive search of online databases (PubMed, Scopus, Web of Science, and China National Knowledge Infrastructure (CNKI)) was conducted to identify all English and Chinese studies published up to August 2020. All case-control studies that assessed plasma/serum zinc levels were eligible for inclusion. Data were analyzed using Comprehensive Meta-Analysis software version 2.2.046 (Biostat, Englewood, NJ, USA). Trial sequential analysis (TSA) was conducted with the trial sequential analysis program. Nineteen case-control studies, involving 1079 RAS cases and 965 controls, were included in the meta-analysis. The pooled results of 19 studies showed that zinc level was significantly lower in RAS patients than in healthy controls (weighted difference in means = - 21.092, 95% CI - 26.695 to - 15.490, I The results suggest a significant association between low serum zinc levels and the occurrence of RAS. Although TSA confirmed a solid conclusion, conducting large-scale studies with the highest standards of quality is encouraged. Determining zinc levels should be considered in diagnosis, management, and prevention of RAS.
Identifiants
pubmed: 33409687
doi: 10.1007/s00784-020-03704-8
pii: 10.1007/s00784-020-03704-8
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Pagination
407-415Références
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