Lipo-PEG nano-ocular formulation successfully encapsulates hydrophilic fluconazole and traverses corneal and non-corneal path to reach posterior eye segment.
Animals
Antifungal Agents
/ administration & dosage
Biofilms
/ drug effects
Cell Line
Chemistry, Pharmaceutical
/ methods
Cornea
/ metabolism
Drug Carriers
/ chemistry
Drug Delivery Systems
Drug Liberation
Female
Fluconazole
/ administration & dosage
Liposomes
Mice
Mice, Inbred C57BL
Nanoparticles
Polyethylene Glycols
/ chemistry
Posterior Eye Segment
/ metabolism
Rabbits
Rats
Swine
Tissue Distribution
Polyethylene glycol
endophthalmitis
eye drops
keratitis
nanostructured lipid carrier
Journal
Journal of drug targeting
ISSN: 1029-2330
Titre abrégé: J Drug Target
Pays: England
ID NLM: 9312476
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
pubmed:
8
1
2021
medline:
24
12
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
The present study describes a special lipid-polyethylene glycol matrix solid lipid nanoparticles (SLNs; 138 nm; -2.07 mV) for ocular delivery. Success of this matrix to encapsulate (entrapment efficiency - 62.09%) a hydrophilic drug, fluconazole (FCZ-SLNs), with no burst release (67% release in 24 h) usually observed with most water-soluble drugs, is described presently. The system showed 164.64% higher flux than the marketed drops (Zocon
Identifiants
pubmed: 33410357
doi: 10.1080/1061186X.2020.1871483
doi:
Substances chimiques
Antifungal Agents
0
Drug Carriers
0
Lipid Nanoparticles
0
Liposomes
0
Polyethylene Glycols
3WJQ0SDW1A
Fluconazole
8VZV102JFY
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM