An update on the role of miR-124 in the pathogenesis of human disorders.
Cancer
Expression
Marker
miR-124
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
20
10
2020
revised:
01
12
2020
accepted:
26
12
2020
pubmed:
8
1
2021
medline:
20
7
2021
entrez:
7
1
2021
Statut:
ppublish
Résumé
MicroRNA-124 (miR-124) is a copious miRNA in the brain, but it is expressed in a wide range of human/animal tissues participating in the pathogenesis of several disorders. Based on its important function in the development of the nervous system, abnormal expression of miR-124 has been detected in nervous system diseases including Alzheimer's disease, Parkinson's disease, Hypoxic-Ischemic Encephalopathy, Huntington's disease, and ischemic stroke. In addition to these conditions, miR-124 contributes to the pathogenesis of cardiovascular disorders, hypertension, and atherosclerosis. Besides, it has been shown to be down-regulated in a wide range of human cancers such as colorectal cancer, breast cancer, gastric cancer, glioma, pancreatic cancer, and other types of cancer. Yet, few studies have reported upregulation of miR-124 in some cancer types. In the current study, we describe the role of miR-124 in these malignant and non-malignant conditions.
Identifiants
pubmed: 33412388
pii: S0753-3322(20)31391-3
doi: 10.1016/j.biopha.2020.111198
pii:
doi:
Substances chimiques
MIRN124 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111198Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.