Symptomatic primary hyperparathyroidism in a young woman presenting with multiple skeletal destructions: a case report and review of literature.
Case report
Hyperparathyroidism
Multiple skeletal destructions
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
07 Jan 2021
07 Jan 2021
Historique:
received:
05
06
2020
accepted:
18
12
2020
entrez:
8
1
2021
pubmed:
9
1
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Here we described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals. A 30-year-old woman was admitted to our hospital due to pain in both knees and walking difficulty that lasted for 6 and 2 years, respectively. Her laboratory test results revealed a high parathyroid hormone level (822 pg/ml) and hypercalcemia (2.52 mmol/L) in the blood. Parathyroid imaging revealed a lumpy concentration of radioactive uptake detected at the lower pole in the right lobe of the thyroid, and was nearly 2.2 cm * 2.4 cm in size. Next, the patient was treated with parathyroidectomy that resulted in a significant improvement in physiological and clinical symptoms. Moreover, the skeletal destruction and bone mineral density were significantly improved after a 5-years follow-up period. Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions.
Sections du résumé
BACKGROUND
BACKGROUND
Multiple pathological manifestations are rarely present in patients with primary hyperparathyroidism (PHPT). Here we described a case of a young woman who presented with multiple skeletal destructions and received an unclear diagnosis at several hospitals.
CASE PRESENTATION
METHODS
A 30-year-old woman was admitted to our hospital due to pain in both knees and walking difficulty that lasted for 6 and 2 years, respectively. Her laboratory test results revealed a high parathyroid hormone level (822 pg/ml) and hypercalcemia (2.52 mmol/L) in the blood. Parathyroid imaging revealed a lumpy concentration of radioactive uptake detected at the lower pole in the right lobe of the thyroid, and was nearly 2.2 cm * 2.4 cm in size. Next, the patient was treated with parathyroidectomy that resulted in a significant improvement in physiological and clinical symptoms. Moreover, the skeletal destruction and bone mineral density were significantly improved after a 5-years follow-up period.
CONCLUSIONS
CONCLUSIONS
Multiple skeletal destructions can be caused by PHPT that should be taken into consideration in young patients with complex bone lesions.
Identifiants
pubmed: 33413306
doi: 10.1186/s12902-020-00669-3
pii: 10.1186/s12902-020-00669-3
pmc: PMC7791781
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5Subventions
Organisme : Beijing Municipal Health Commission
ID : BMHC2019-9
Organisme : Beijing Natural Science Foundation
ID : L192049
Organisme : Beijing Jishuitan Hospital's 'Discipline new star' Plan
ID : XKXX201604
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