Novel Linkage Peaks Discovered for Diabetic Nephropathy in Individuals With Type 1 Diabetes.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
13
02
2020
accepted:
01
01
2021
pubmed:
9
1
2021
medline:
24
8
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
Genome-wide association studies (GWAS) and linkage studies have had limited success in identifying genome-wide significantly linked regions or risk loci for diabetic nephropathy (DN) in individuals with type 1 diabetes (T1D). As GWAS cohorts have grown, they have also included more documented and undocumented familial relationships. Here we computationally inferred and manually curated pedigrees in a study cohort of >6,000 individuals with T1D and their relatives without diabetes. We performed a linkage study for 177 pedigrees consisting of 452 individuals with T1D and their relatives using a genome-wide genotyping array with >300,000 single nucleotide polymorphisms and PSEUDOMARKER software. Analysis resulted in genome-wide significant linkage peaks on eight chromosomal regions from five chromosomes (logarithm of odds score >3.3). The highest peak was localized at the HLA region on chromosome 6p, but whether the peak originated from T1D or DN remained ambiguous. Of other significant peaks, the chromosome 4p22 region was localized on top of
Identifiants
pubmed: 33414249
pii: db20-0158
doi: 10.2337/db20-0158
pmc: PMC8928864
doi:
Banques de données
figshare
['10.2337/figshare.13507995']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
986-995Subventions
Organisme : NIDDK NIH HHS
ID : K99 DK127196
Pays : United States
Informations de copyright
© 2021 by the American Diabetes Association.
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