Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.

Anxiety / genetics DNA Methylation / genetics Epigenesis, Genetic / genetics Epigenome Epigenomics Female Humans Pregnancy

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
06 2021
Historique:
received: 07 04 2020
accepted: 30 11 2020
revised: 31 10 2020
pubmed: 9 1 2021
medline: 12 10 2021
entrez: 8 1 2021
Statut: ppublish

Résumé

Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.

Identifiants

DOI: 10.1038/s41380-020-00976-0 PMID: 33414500 PMC: PMC8595870
pubmed: 33414500
doi: 10.1038/s41380-020-00976-0
pii: 10.1038/s41380-020-00976-0
pmc: PMC8595870
mid: NIHMS1712379
doi:

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1832-1845

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES014930
Pays : United States
Organisme : British Heart Foundation
ID : AA/18/7/34219
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/17/60/33474
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES006096
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095606
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS047537
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111108
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 ES049019
Pays : United States
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : N01ES75558
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114396
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R00 ES024116
Pays : United States
Organisme : Department of Health
ID : NF-SI-0616-10102
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 084762MA
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD068437
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 ES025045
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES013744
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S036520/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CS/16/4/32482
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S009310/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K021656/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R21 HD085849
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR013945
Pays : United States
Organisme : Wellcome Trust
ID : WT101597MA
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R01 ES021357
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Sara Sammallahti (S)

Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
Harvard T.H. Chan School of Public Health, Department of Social and Behavioral Science, Boston, MA, USA.
University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.

Andrea P Cortes Hidalgo (AP)

Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
ORCID: 0000-0002-7426-6181

Samuli Tuominen (S)

University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.
ORCID: 0000-0002-1879-0739

Anni Malmberg (A)

University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.

Rosa H Mulder (RH)

Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
Leiden University, Institute of Education and Child Studies, Leiden, The Netherlands.

Kelly J Brunst (KJ)

University of Cincinnati, College of Medicine, Department of Environmental Health, Cincinnati, OH, USA.

Silvia Alemany (S)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
ORCID: 0000-0002-7925-6767

Nancy S McBride (NS)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.

Paul Yousefi (P)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
ORCID: 0000-0003-3284-3240

Jonathan A Heiss (JA)

Icahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.

Nia McRae (N)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Christian M Page (CM)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.

Jianping Jin (J)

Westat, Durham, NC, USA.
ORCID: 0000-0002-3774-1609

Giancarlo Pesce (G)

INSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.
Sorbonne Université, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Paris, France.
ORCID: 0000-0003-4925-6325

Doretta Caramaschi (D)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.

Sheryl L Rifas-Shiman (SL)

Harvard Medical School, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Nastassja Koen (N)

University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
University of Cape Town, Neuroscience Institute, Cape Town, South Africa.

Charleen D Adams (CD)

Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.

Maria C Magnus (MC)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Nour Baïz (N)

INSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.
Sorbonne Université, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Paris, France.

Andrew Ratanatharathorn (A)

Columbia University, Department of Epidemiology, New York City, NY, USA.
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
ORCID: 0000-0001-9855-0438

Darina Czamara (D)

Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
ORCID: 0000-0001-7381-904X

Siri E Håberg (SE)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Elena Colicino (E)

Icahn School of Medicine at Mount Sinai, Department of Environmental Medicine and Public Health, New York, NY, USA.

Andrea A Baccarelli (AA)

Columbia University Mailman School of Public Health, Precision Environmental Health Lab, New York, NY, USA.
ORCID: 0000-0002-3436-0640

Andres Cardenas (A)

University of California, Division of Environmental Health Sciences, School of Public Health, Berkeley, CA, USA.
ORCID: 0000-0003-2284-3298

Dawn L DeMeo (DL)

Brigham and Women's Hospital, Channing Division of Network Medicine, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Deborah A Lawlor (DA)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
ORCID: 0000-0002-6793-2262

Caroline L Relton (CL)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.

Janine F Felix (JF)

Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Department of Pediatrics, Rotterdam, The Netherlands.
ORCID: 0000-0002-9801-5774

Marinus H van IJzendoorn (MH)

Erasmus University Rotterdam, Department of Psychology, Education, and Child Studies, Rotterdam, The Netherlands.
University of Cambridge, School of Clinical Medicine, Cambridge, UK.
ORCID: 0000-0003-1144-454X

Marian J Bakermans-Kranenburg (MJ)

Leiden University, Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Vrije Universiteit Amsterdam, Clinical Child & Family Studies, Amsterdam, The Netherlands.

Eero Kajantie (E)

Finnish Institute for Health and Welfare, Helsinki, Finland.
Oulu University Hospital and University of Oulu, PEDEGO Research Unit, MRC Oulu, Oulu, Finland.
Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway.

Katri Räikkönen (K)

University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.

Jordi Sunyer (J)

ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Gemma C Sharp (GC)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
ORCID: 0000-0003-2906-4035

Lotte C Houtepen (LC)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
ORCID: 0000-0003-1442-8852

Ellen A Nohr (EA)

University of Southern Denmark, Institute of Clinical Research and Department of Gynaecology and Obstetrics, Odense, Denmark.

Thorkild I A Sørensen (TIA)

University of Bristol, MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, Bristol, UK.
University of Copenhagen, Faculty of Health and Medical Sciences, Department of Public Health, Copenhagen, Denmark.
University of Copenhagen, Faculty of Medical and Health Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark.

Martha M Téllez-Rojo (MM)

National Institute of Public Health, Center for Nutrition and Health Research, Cuernavaca, Mor, Mexico.

Robert O Wright (RO)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Isabella Annesi-Maesano (I)

INSERM UMR-S 1136, EPAR, Saint-Antoine Medical School, Paris, France.
Sorbonne Université, Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Paris, France.
ORCID: 0000-0002-6340-9300

John Wright (J)

Bradford Institute for Health Research, Bradford Teaching Hospitals, NHS Foundation Trust, Bradford, UK.

Marie-France Hivert (MF)

Harvard Medical School, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Massachusetts General Hospital, Diabetes Unit, Boston, MA, USA.

Rosalind J Wright (RJ)

Icahn School of Medicine at Mount Sinai, Environmental Medicine & Public Health, Institute for Exposomic Research, New York, NY, USA.

Heather J Zar (HJ)

University of Cape Town, Department of Paediatrics and Child Health, Cape Town, South Africa.
South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, Cape Town, Cape Town, South Africa.

Dan J Stein (DJ)

University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
University of Cape Town, Neuroscience Institute, Cape Town, South Africa.
ORCID: 0000-0001-7218-7810

Stephanie J London (SJ)

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
ORCID: 0000-0003-4911-5290

Charlotte A M Cecil (CAM)

Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands.
Erasmus MC, University Medical Center Rotterdam, Department of Epidemiology, Rotterdam, The Netherlands.
Leiden University Medical Center, Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden, The Netherlands.

Henning Tiemeier (H)

Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, The Netherlands. tiemeier@hsph.harvard.edu.
Erasmus MC, University Medical Center Rotterdam, Generation R Study Group, Rotterdam, The Netherlands. tiemeier@hsph.harvard.edu.
Harvard T.H. Chan School of Public Health, Department of Social and Behavioral Science, Boston, MA, USA. tiemeier@hsph.harvard.edu.
ORCID: 0000-0002-4395-1397

Jari Lahti (J)

University of Helsinki, Department of Psychology and Logopedics, Helsinki, Finland.
ORCID: 0000-0002-4310-5297

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal anxiety during pregnancy and newborn...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal anxiety during pregnancy and newborn...