A cross-platform approach identifies genetic regulators of human metabolism and health.

Diabetes Mellitus, Type 2 / genetics Eye Diseases / genetics Gene Frequency / genetics Genetic Loci Genetic Pleiotropy Genome, Human Glucagon-Like Peptide-2 Receptor / genetics Glycine / metabolism Health Humans Linear Models Mendelian Randomization Analysis Metabolism / genetics Metabolism, Inborn Errors / genetics Metabolome / genetics Mutation, Missense / genetics Phenotype Polymorphism, Single Nucleotide / genetics Retinal Telangiectasis / genetics Sample Size Serine / metabolism

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
01 2021
Historique:
received: 04 02 2020
accepted: 20 11 2020
entrez: 8 1 2021
pubmed: 9 1 2021
medline: 11 2 2021
Statut: ppublish

Résumé

In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10

Identifiants

DOI: 10.1038/s41588-020-00751-5 PMID: 33414548 PMC: PMC7612925
pubmed: 33414548
doi: 10.1038/s41588-020-00751-5
pii: 10.1038/s41588-020-00751-5
pmc: PMC7612925
mid: EMS146224
doi:

Substances chimiques

GLP2R protein, human 0
Glucagon-Like Peptide-2 Receptor 0
Serine 452VLY9402
Glycine TE7660XO1C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-64

Subventions

Organisme : Medical Research Council
ID : MR/L003120/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P01836X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13030
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106263/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13046
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106262/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : Chief Scientist Office
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13048
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/09/002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/3
Pays : United Kingdom
Organisme : Department of Health
ID : BTRU-2014-10024
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204623
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C864/A14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S003746/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L00002/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT083442AIA
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P011705/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A090_1006
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0500300
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/12/2/29428
Pays : United Kingdom

Investigateurs

Melanie Bahlo (M)

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Auteurs

Luca A Lotta (LA)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Maik Pietzner (M)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Isobel D Stewart (ID)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Laura B L Wittemans (LBL)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

Chen Li (C)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Roberto Bonelli (R)

Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.

Johannes Raffler (J)

Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
ORCID: 0000-0003-2495-4020

Emma K Biggs (EK)

Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.

Clare Oliver-Williams (C)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Homerton College, University of Cambridge, Cambridge, UK.

Victoria P W Auyeung (VPW)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-0823-3963

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3137-6337

Eleanor Wheeler (E)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-8616-6444

Ellie Paige (E)

National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia.
ORCID: 0000-0003-0855-9872

Praveen Surendran (P)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Gregory A Michelotti (GA)

Metabolon Inc, Durham, NC, USA.

Robert A Scott (RA)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3634-3016

Stephen Burgess (S)

MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-5365-8760

Verena Zuber (V)

MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
ORCID: 0000-0001-9827-1877

Eleanor Sanderson (E)

MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0001-5188-5775

Albert Koulman (A)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-9998-051X

Fumiaki Imamura (F)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-6841-8396

Nita G Forouhi (NG)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-5041-248X

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Julian L Griffin (JL)

Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Angela M Wood (AM)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
The Alan Turing Institute, London, UK.

Gabi Kastenmüller (G)

Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
ORCID: 0000-0002-2368-7322

John Danesh (J)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Cambridge Biomedical Research Centre, National Institute for Health Research, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.

Adam S Butterworth (AS)

British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Cambridge Biomedical Research Centre, National Institute for Health Research, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
ORCID: 0000-0002-6915-9015

Fiona M Gribble (FM)

Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.

Frank Reimann (F)

Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-9399-6377

Melanie Bahlo (M)

Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0001-5132-0774

Eric Fauman (E)

Internal Medicine Research Unit, Pfizer Worldwide Research, Cambridge, MA, USA.
ORCID: 0000-0002-9739-0249

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK. claudia.langenberg@mrc-epid.cam.ac.uk.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. claudia.langenberg@mrc-epid.cam.ac.uk.
Computational Medicine, Berlin Institute of Health (BIH), Charité University Medicine, Berlin, Germany. claudia.langenberg@mrc-epid.cam.ac.uk.
ORCID: 0000-0002-5017-7344

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › A cross-platform approach identifies genetic...
questionsmedicales.fr › Maladies de l'oeil › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Pléiotropie › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › A cross-platform approach identifies genetic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone gastrointestinale › Récepteurs des peptides similaires au glucagon › Récepteur du peptide-2 similaire au glucagon › A cross-platform approach identifies genetic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Glycine › A cross-platform approach identifies genetic...
questionsmedicales.fr › Caractéristiques de la population › Santé › A cross-platform approach identifies genetic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A cross-platform approach identifies genetic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › A cross-platform approach identifies genetic...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › A cross-platform approach identifies genetic...
questionsmedicales.fr › Métabolisme › A cross-platform approach identifies genetic...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › A cross-platform approach identifies genetic...
questionsmedicales.fr › Métabolisme › Métabolome › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › A cross-platform approach identifies genetic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A cross-platform approach identifies genetic...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Télangiectasie › Télangiectasie rétinienne › A cross-platform approach identifies genetic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Taille de l'échantillon › A cross-platform approach identifies genetic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Sérine › A cross-platform approach identifies genetic...