A Contemporary Approach to Diagnosis and Treatment of Combined Hepatocellular-Cholangiocarcinoma.
genetic aberrations
liver transplantation
loco-regional therapy
mixed liver cancer
primary liver cancer
Journal
Current hepatology reports
ISSN: 2195-9595
Titre abrégé: Curr Hepatol Rep
Pays: United States
ID NLM: 101631871
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
8
1
2021
pubmed:
9
1
2021
medline:
9
1
2021
Statut:
ppublish
Résumé
To provide updates on terminology, epidemiology, diagnosis, and treatment of combined hepatocellular-cholangiocarcinoma (cHCC-CCA). cHCC-CCAs are tumors that in the same nodule contain a variable degree of HCC and CCA components with a transition zone. cHCC-CCAs develop in cirrhotic and non-cirrhotic livers like and is associated with poor outcomes. Mutations in cHCC-CCAs are a heterogeneous group of primary liver cancers with unique biological behavior. Multicenter studies are required for a molecular analysis to inform novel therapeutic approaches, and understand epidemiology and benefits of liver transplantation, liver-directed and targeted therapies for this rare aggressive cancer.
Identifiants
pubmed: 33415066
doi: 10.1007/s11901-020-00556-4
pmc: PMC7785105
mid: NIHMS1642777
doi:
Types de publication
Journal Article
Langues
eng
Pagination
478-485Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK122114
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest Olga Raevskaya, Henry Appelman, and Natalita Razumilava declare that they have no conflict of interest
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