Kaposi's sarcoma-associated herpesvirus and extracellular vesicles.
Kaposi's sarcoma
Kaposi's sarcoma-associated herpesvirus
extracellular vesicles
microRNA
primary effusion lymphoma
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
04
01
2021
received:
15
12
2020
accepted:
05
01
2021
pubmed:
9
1
2021
medline:
9
10
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
Kaposi's sarcoma-associated herpesvirus (KSHV) represents the etiological agent for several human malignancies, including Kaposi's Sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), which develop mainly in immunocompromised patients. KSHV has established many strategies to hijack and thwart the host's immune responses, including through the use of extracellular vesicles (EVs). EVs represent a significant mode of intercellular communication as they carry a variety of molecules that can be delivered from cell-to-cell. EVs are now recognized as one of the major players in immune system development and function during both innate and adaptive immune responses. In the current mini-review, we summarize recent findings on how KSHV utilizes EVs to create favorable environments for viral spread and persistence while evading immune responses. We also discuss the limitations and unanswered questions in this field and the potential areas for related immunotherapies.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3294-3299Informations de copyright
© 2021 Wiley Periodicals LLC.
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