Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes.


Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
22 03 2021
Historique:
received: 07 12 2020
pubmed: 9 1 2021
medline: 15 7 2021
entrez: 8 1 2021
Statut: ppublish

Résumé

We present a new class of DNA-based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding-upon-repair DNA nanoswitches are synthetic DNA sequences containing O

Identifiants

pubmed: 33415794
doi: 10.1002/anie.202016223
pmc: PMC8783695
mid: NIHMS1771493
doi:

Substances chimiques

DNA 9007-49-2
O(6)-Methylguanine-DNA Methyltransferase EC 2.1.1.63

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7283-7289

Subventions

Organisme : NEI NIH HHS
ID : R01 EY027440
Pays : United States
Organisme : National Institute of Health under Grant
ID : R01-EY027440

Informations de copyright

© 2020 Wiley-VCH GmbH.

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Auteurs

Nada Farag (N)

Department of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.

Rosanna Mattossovich (R)

Institute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.

Rosa Merlo (R)

Institute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.

Łukasz Nierzwicki (Ł)

Department of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA, 52512, USA.

Giulia Palermo (G)

Department of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA, 52512, USA.
Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside, CA, 52512, USA.

Alessandro Porchetta (A)

Department of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.

Giuseppe Perugino (G)

Institute of Biosciences and BioResources, National Research Council of Italy, Via Pietro Castellino 111, 80131, Naples, Italy.

Francesco Ricci (F)

Department of Chemistry, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.

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Classifications MeSH