Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus.
CCHFV
Crimean-Congo hemorrhagic fever virus
immunology
infectious disease
inflammation
microbiology
mouse model
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
10
10
2020
accepted:
07
01
2021
pubmed:
9
1
2021
medline:
29
1
2022
entrez:
8
1
2021
Statut:
epublish
Résumé
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite causing severe disease in humans, our understanding of the host and viral determinants of CCHFV pathogenesis are limited. A major limitation in the investigation of CCHF has been the lack of suitable small animal models. Wild-type mice are resistant to clinical isolates of CCHFV and consequently, mice must be deficient in type I interferon responses to study the more severe aspects of CCHFV. We report here a mouse-adapted variant of CCHFV that recapitulates in adult, immunocompetent mice the severe CCHF observed in humans. This mouse-adapted variant of CCHFV significantly improves our ability to study host and viral determinants of CCHFV-induced disease in a highly tractable mouse model.
Identifiants
pubmed: 33416494
doi: 10.7554/eLife.63906
pii: 63906
pmc: PMC7811403
doi:
pii:
Substances chimiques
Interferon Type I
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
DH, KM, SL, FF, AO, BS, DS, HF No competing interests declared
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