Effects of dietary restriction on neuroinflammation in neurodegenerative diseases.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
19
05
2020
revised:
29
09
2020
accepted:
30
11
2020
entrez:
8
1
2021
pubmed:
9
1
2021
medline:
10
9
2021
Statut:
ppublish
Résumé
Recent and accumulating work in experimental animal models and humans shows that diet has a much more pervasive and prominent role than previously thought in modulating neuroinflammatory and neurodegenerative mechanisms leading to some of the most common chronic central nervous system (CNS) diseases. Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, among others. This review discusses these findings and their potential application to the prevention and treatment of CNS neuroinflammatory diseases and the promotion of healthy brain aging.
Identifiants
pubmed: 33416892
pii: 211666
doi: 10.1084/jem.20190086
pmc: PMC7802371
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102633
Pays : United States
Informations de copyright
© 2021 Fontana et al.
Déclaration de conflit d'intérêts
Disclosures: L. Ghezzi was supported by the Italian Multiple Sclerosis Society research fellowship (FISM 2018/B/1) and later on by the National Multiple Sclerosis Society Post-Doctoral Fellowship (FG-1907-34474). A.H. Cross reported personal fees from Biogen, Celgene, EMD Serono, Genentech, Greenwich Biosciences, Novartis, Janssen, TG Therapeutics, and Roche; and grants from EMD Serono and Genentech outside the submitted work. No other disclosures were reported.
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