Population pharmacokinetic model development and exposure-response analysis of vincristine in patients with malignant lymphoma.
Malignant lymphoma
Pharmacodynamics
Population pharmacokinetics
Vincristine
Journal
Cancer chemotherapy and pharmacology
ISSN: 1432-0843
Titre abrégé: Cancer Chemother Pharmacol
Pays: Germany
ID NLM: 7806519
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
27
07
2020
accepted:
25
12
2020
pubmed:
9
1
2021
medline:
25
8
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
Vincristine (VCR) is a key drug for treating various malignancies. However, few data are available on the pharmacokinetics of VCR, especially in adult patients. The objective of this study was to clarify the population pharmacokinetics and exposure-response relationships of VCR in adult malignant lymphoma patients. Blood samples were collected from patients who were administered R-CHOP-like regimens, and the VCR plasma concentration was determined using liquid chromatography-mass spectrometry. Using NONMEM software, population pharmacokinetic parameters were estimated, and covariates were evaluated. The relationships between the individual parameters and adverse events or therapeutic effects were also investigated. Plasma concentrations were measured in 30 patients. In the final population pharmacokinetics model, body surface area and age were incorporated into clearance as significant covariates. The inter-individual variations in clearance and volume of distribution in the central and third compartments were 17.0, 26.6, and 66.3%, respectively, and the residual variability in the plasma concentration was 23.8%. Although the variability observed in the volume of distribution was large, good predictability was obtained in the individual estimation. The severity of anemia and peripheral neuropathy was correlated with clearance and peak concentration, respectively (adjusted P = 0.040 and 0.024, respectively). In diffuse large B cell lymphoma patients, those with higher area under the curve and dose experienced longer progression-free survival (P = 0.023 and 0.013, respectively). The population pharmacokinetics of VCR were evaluated in adult malignant lymphoma patients. VCR pharmacokinetic data could explain in part the adverse events and prognosis of these patients.
Identifiants
pubmed: 33416909
doi: 10.1007/s00280-020-04220-y
pii: 10.1007/s00280-020-04220-y
doi:
Substances chimiques
Vincristine
5J49Q6B70F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
501-511Références
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