Relationship between brain AD biomarkers and episodic memory performance in healthy aging.
Aging
Alzheimer’s disease
Biomarkers
Episodic memory
Hippocampus
Journal
Brain and cognition
ISSN: 1090-2147
Titre abrégé: Brain Cogn
Pays: United States
ID NLM: 8218014
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
24
09
2020
revised:
23
12
2020
accepted:
27
12
2020
pubmed:
9
1
2021
medline:
28
4
2021
entrez:
8
1
2021
Statut:
ppublish
Résumé
The presence of brain biomarkers can be observed decades before the first clinical symptoms of Alzheimer's disease (AD). We aimed to determine whether associations between biomarkers and episodic memory performance already exist in a healthy late middle-aged population or only in participants over 60 years old. Performance at the Free and Cued Selective Reminding Test [FCSRT], the Logical Memory test and the Mnemonic Similarity Task [MST] was determined in sixty healthy participants (50-70 y.) with a negative status for amyloid-beta (Aβ) biomarker. We assessed Aβ cortical level and tau/neuroinflammation burden using PET scanner, and hippocampal atrophy with MRI scanner. Generalized linear mixed models showed that MST scores (recognition and pattern separation) were positively associated with hippocampal volume in participants over 60 years. No association between memory performance and Aβ and tau/neuroinflammation burden was found in the older or in the younger age group. This suggests that visual recognition memory and discrimination of lures may constitute early cognitive markers of memory decline in an older population.
Identifiants
pubmed: 33418512
pii: S0278-2626(20)30283-9
doi: 10.1016/j.bandc.2020.105680
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105680Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.